Angiogenesis: from plants to blood vessels

被引:193
作者
Fan, Tai-Ping [1 ]
Yeh, Ju-Ching
Leung, Kar Wah
Yue, Patrick Y. K.
Wong, Ricky N. S.
机构
[1] Univ Cambridge, Dept Pharmacol, Angiogenesis & Tradit Chinese Med Lab, Cambridge CB2 1PD, England
[2] Univ Cambridge, Rosie Hosp, Dept Obstet & Gynaecol, Cambridge CB2 2SW, England
[3] Hong Kong Baptist Univ, Dept Biol, Fac Sci, Hong Kong, Hong Kong, Peoples R China
[4] Hong Kong Baptist Univ, Sch Chinese Med, R&D Div, Hung Lai Ching Lab Biomed Sci, Hong Kong, Hong Kong, Peoples R China
关键词
D O I
10.1016/j.tips.2006.04.006
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Angiogenesis is a major pathological component of diseases such as cancer and coronary heart disease. Although major advances have been made and encouraging clinical results obtained, safer and more effective approaches are required. The identification of new drugs from plants has a long and successful history, and certain proangiogenic and antiangiogenic plant components have been used in traditional Chinese medicine (TCM) for thousands of years. Similar to Western combination therapy, TCM uses mixtures of plant extracts, termed fufang, to maximize efficacy and minimize adverse effects or toxicity. More evidence-based research and chemical optimization of these compounds could further enhance the effectiveness of these plant-based medicines in angiotherapy.
引用
收藏
页码:297 / 309
页数:13
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