The Role of Mitophagy in Innate Immunity

被引：203

作者：

Gkikas, Ilias ^{[1
,2
]}

Palikaras, Konstantinos ^{[1
]}

Tavernarakis, Nektarios ^{[1
,3
]}

机构：

[1] Fdn Res & Technol Hellas, Inst Mol Biol & Biotechnol, Iraklion, Greece

[2] Univ Crete, Dept Biol, Iraklion, Greece

[3] Univ Crete, Dept Basic Sci, Fac Med, Iraklion, Greece

来源：

FRONTIERS IN IMMUNOLOGY | 2018年 / 9卷

基金：

欧洲研究理事会;

关键词：

autophagy; energy homeostasis; immunity; inflammation; metabolism; macrophages; mitochondria; mitophagy; NF-KAPPA-B; NLRP3 INFLAMMASOME ACTIVATION; PINK1/PARKIN-RELATED PARKINSONS-DISEASE; RECEPTOR-MEDIATED MITOPHAGY; NIX RESTORES MITOPHAGY; E3 UBIQUITIN LIGASE; MACROPHAGE ACTIVATION; MITOCHONDRIAL-FUNCTION; DAMAGED MITOCHONDRIA; SELECTIVE AUTOPHAGY;

D O I：

10.3389/fimmu.2018.01283

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Mitochondria are cellular organelles essential for multiple biological processes, including energy production, metabolites biosynthesis, cell death, and immunological responses among others. Recent advances in the field of immunology research reveal the pivotal role of energy metabolism in innate immune cells fate and function. Therefore, the maintenance of mitochondrial network integrity and activity is a prerequisite for immune system homeostasis. Mitochondrial selective autophagy, known as mitophagy, surveils mitochondrial population eliminating superfluous and/or impaired organelles and mediating cellular survival and viability in response to injury/trauma and infection. Defective removal of damaged mitochondria leads to hyperactivation of inflammatory signaling pathways and subsequently to chronic systemic inflammation and development of inflammatory diseases. Here, we review the molecular mechanisms of mitophagy and highlight its critical role in the innate immune system homeostasis.

引用

页数：15

共 178 条

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