Incorporation of 2-hydroxy-4-methoxybenzyl protection during peptide synthesis via reductive alkylation on the solid phase

被引：16

作者：

Ede, NJ

Ang, KH

James, IW

Bray, AM

机构：

[1] Chiron Mimotopes Ply. Ltd., Clayton, Vic. 3168

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 50期

关键词：

D O I：

10.1016/S0040-4039(96)02095-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A method has been developed for the synthesis of Hmb protected amino acid residues via reductive alkylation of 2-hydroxy-4-methoxybenzaldehyde with resin bound amino acids/peptides. The methodology potentially allows incorporation of Hmb protected amino acids at any point in the synthesis of difficult peptides. Synthesis of ACP (65-74) illustrates the method. Copyright (C) 1996 Elsevier Science Ltd

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页码：9097 / 9100

页数：4

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