Characterization of a human papillomavirus type 16 variant-dependent neutralizing epitope

被引:93
作者
Roden, RBS
Armstrong, A
Haderer, P
Christensen, ND
Hubbert, NL
Lowy, DR
Schiller, JT
Kirnbauer, R
机构
[1] PENN STATE UNIV, MILTON S HERSHEY MED CTR, DEPT PATHOL, HERSHEY, PA 17033 USA
[2] UNIV VIENNA, SCH MED, DEPT DERMATOL, DIV IMMUNOL ALLERGY & INFECT DIS, A-1090 VIENNA, AUSTRIA
关键词
D O I
10.1128/JVI.71.8.6247-6252.1997
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
We have determined that three type-specific and conformationally dependent monoclonal antibodies, H16.E70, H16.U4, and H16.V5, neutralize pseudotype human papillomavirus type 16 (HPV16) virions in vitro. H16.U4 and K16.V5 neutralized pseudotype virions derived from the German HPV16 variant 114K and the Zairian variant Z-1194 with equal efficiency. In contrast, neutralization of Z-1194 pseudotype virions by H16.E70 was two orders of magnitude weaker than neutralization of 114K pseudotype virions. This difference correlated with enzyme-linked immunosorbent assay reactivity of H16.E70 to L1 virus-like particles of the two variants. A substitution at residue 282 of L1 was responsible for this differential reactivity, suggesting that this residue constitutes part of the H16.E70 epitope.
引用
收藏
页码:6247 / 6252
页数:6
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