SN2 vs. E2 on quaternary centres:: an application to the synthesis of enantiopure β2,2-amino acids

被引：47

作者：

Avenoza, A ^{[1
]}

Busto, JH ^{[1
]}

Corzana, F ^{[1
]}

Jiménez-Osés, G ^{[1
]}

Peregrina, JM ^{[1
]}

机构：

[1] Univ La Rioja, Dept Quim, Grp Sintesis Quim Rioja, CSIC,UA, E-26006 Logrono, Spain

来源：

CHEMICAL COMMUNICATIONS | 2004年 / 08期

关键词：

D O I：

10.1039/b400282b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

S(N)2 and E2 competing reactions in cyclic sulfamidates can be modulated by the change of an amide group to an ester group attached to the quaternary carbon activated for the nucleophilic attack, allowing an easy approach to enantiopure alpha,alpha-disubstituted beta-amino acids.

引用

页码：980 / 981

页数：2

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