Drug insight: statins and gastrointestinal cancer

被引：9

作者：

Bhuket, Taft P. ^{[1
]}

Higgins, Peter D. R. ^{[1
]}

机构：

[1] Univ Michigan, Div Gastroenterol, Dept Internal Med, Ann Arbor, MI 48109 USA

来源：

NATURE CLINICAL PRACTICE GASTROENTEROLOGY & HEPATOLOGY | 2006年 / 3卷 / 10期

关键词：

chemoprevention; gastrointestinal cancer; statins;

D O I：

10.1038/ncpgasthep0603

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Statins are popular lipid-lowering drugs that have had a great impact on the primary and secondary prevention of cardiovascular diseases. Basic and clinical research have also revealed that statins have biologic activities that go beyond lipid lowering, and suggest that they might have other therapeutic benefits. Perhaps the most exciting of these additional biologic effects is the finding that statins can exert an anticancer effect on cultured cancer cells, and in animal models. Clinical studies of statins for the treatment and prevention of cancer have, however, produced conflicting results. This review critically evaluates the current body of literature on the role of statins in the treatment and prevention of gastrointestinal cancers, with particular focus on clinical and observational studies.

引用

页码：552 / 562

页数：11

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