A natural inter-genotypic (2b/1b) recombinant of hepatitis C virus in the Philippines

被引：73

作者：

Kageyama, Seiji

Agdamag, Dorothy M.

Alesna, Evelyn T.

Leano, Prisca S.

Heredia, Anna Marie L.

Abellanosa-Tac-An, Ilya P.

Jereza, Lourdes D.

Tanimoto, Tomoaki

Yamamura, Jun-ichi

Ichimura, Hiroshi

机构：

[1] Kanazawa Univ, Dept Viral Infect & Int Hlth, Grad Sch Med Sci, Kanazawa, Ishikawa 9208640, Japan

[2] San Lazaro Hosp, STD AIDS Cooperat Cent Lab, Manila, Philippines

[3] Cebu Ctr Infect Dis, Cebu, Philippines

[4] Cebu City Hlth Off, Cebu, Philippines

[5] Univ So Philippines, Cebu, Philippines

[6] Kanazawa Med Univ, Dept Pediat, Uchinada, Ishikawa 92002, Japan

来源：

JOURNAL OF MEDICAL VIROLOGY | 2006年 / 78卷 / 11期

关键词：

HCV; recombination; subtype-2b; subtype-1b; NS3; protein; Philippines;

D O I：

10.1002/jmv.20714

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The prevalence study and the characterization of hepatitis C virus (HCV) was carried out in the Philippines and the sequence determination of the 5-untranslated region (5'-UTR)-Core and the NS5B regions of HCV was carried out in this study. An HCV strain (SE-03-07-1689) collected in Metro Manila, Philippines, belonged to discordant subtypes, 2b and 1b in 5'-UTR-Core and NS5B regions, respectively. The 9.3 kb sequence of this strain including the entire open reading frame was compared with those of the reference strains retrieved from the HCV sequences database (GenBank/EMBL/DDBJ) and indicated a recombination event. The computation of the sequence similarity mapped a crossover point within the NS3 region. This is the second report on the inter-genotype recombinant of HCV and the third when an intra-genotype recombinant is included. This recombinant strain, SE-03-07-1689, is designated tentatively as RF3_2b/1b according to the suggestions used for the other two HCV recombinants.

引用

页码：1423 / 1428

页数：6

共 35 条

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