Dietary Cocoa Prevents Aortic Remodeling and Vascular Oxidative Stress in Diabetic Rats

被引:11
作者
Alvarez-Cilleros, David [1 ]
Elvira Lopez-Oliva, Maria [2 ]
Morales-Cano, Daniel [3 ,4 ,5 ]
Barreira, Bianca [3 ,4 ,5 ]
Perez-Vizcaino, Francisco [3 ,4 ,5 ]
Goya, Luis [1 ]
Ramos, Sonia [1 ]
Angeles Martin, Maria [1 ,6 ]
机构
[1] Inst Ciencia & Tecnol Alimentos & Nutr, Madrid 28040, Spain
[2] Univ Complutense Madrid, Fac Farm, Dept Fisiol, E-28040 Madrid, Spain
[3] Univ Complutense Madrid, Fac Med, Dept Farmacol, E-28040 Madrid, Spain
[4] ISCIII, CIBER Enfermedades Resp, Madrid 28029, Spain
[5] Inst Invest Sanitaria Gregorio Maranon, Madrid 28007, Spain
[6] ISCIII, CIBER Diabet & Enfermedades Metab Asociadas, Madrid 28029, Spain
关键词
aortic stiffening; cocoa diet; obesity; polyphenols; Zucker diabetic fatty rats; NADPH OXIDASES; METALLOTHIONEIN; SULFORAPHANE; FLAVONOIDS; PRESSURE; CELL;
D O I
10.1002/mnfr.201900044
中图分类号
TS2 [食品工业];
学科分类号
100403 [营养与食品卫生学];
摘要
Scope The aim of the present study is to investigate the potential protective effect of a cocoa-rich diet on functional and structural vascular alterations in diabetes and the mechanism involved. Methods and results Male Zucker diabetic fatty (ZDF) rats are fed on a standard (ZDF-C) or cocoa-rich diet (ZDF-Co) from week 10 to 20 of life. Diabetic ZDF-C rats showed increased blood pressure and enhanced aortic stiffness, as demonstrated by the increased pulse pressure and the augmented aortic medial thickness with loss and disruption of elastic fibres. Interestingly, cocoa intake strongly avoided all these adverse effects and reduced aortic oxidative stress. Mechanistically, cocoa diet prevented sirtuin-1 (SIRT-1) depletion and increased NADPH oxidases (NOXs) and reactive oxygen species production as well as reduced active nuclear factor E2 related factor 2 (Nrf2) and their antioxidant products. Conclusion The results demonstrate for the first time that a cocoa-rich diet strongly prevents aortic stiffening and remodeling in diabetic animals and avoids aortic oxidative stress. It is suggested that this effect could be mediated via its effects on SIRT-1, NOXs, and Nrf2.
引用
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页数:9
相关论文
共 37 条
[21]
Resveratrol inhibits inflammation and ameliorates insulin resistant endothelial dysfunction via regulation of AMP-activated protein kinase and sirtuin 1 activities [J].
Liu, Zifeng ;
Jiang, Cuihua ;
Zhang, Jinghua ;
Liu, Baolin ;
Du, Qun .
JOURNAL OF DIABETES, 2016, 8 (03) :324-335
[22]
Cocoa, Blood Pressure, and Vascular Function [J].
Ludovici, Valeria ;
Barthelmes, Jens ;
Ngele, Matthias P. ;
Enseleit, Frank ;
Ferri, Claudio ;
Flammer, Andreas J. ;
Ruschitzka, Frank ;
Sudano, Isabella .
FRONTIERS IN NUTRITION, 2017, 4
[23]
Zinc protects against diabetes-induced pathogenic changes in the aorta: roles of metallothionein and nuclear factor (erythroid-derived 2)-like 2 [J].
Miao, Xiao ;
Wang, Yonggang ;
Sun, Jian ;
Sun, Weixia ;
Tan, Yi ;
Cai, Lu ;
Zheng, Yang ;
Su, Guanfang ;
Liu, Quan ;
Wang, Yuehui .
CARDIOVASCULAR DIABETOLOGY, 2013, 12
[24]
Moderate Effect of Flavonoids on Vascular and Renal Function in Spontaneously Hypertensive Rats [J].
Paredes, Maria D. ;
Romecin, Paola ;
Atucha, Noemi M. ;
O'Valle, Francisco ;
Castillo, Julian ;
Clara Ortiz, Maria ;
Garcia-Estan, Joaquin .
NUTRIENTS, 2018, 10 (08)
[25]
Ramirez-Sanchez I, 2018, FOOD FUNCT, V9, P4802, DOI [10.1039/c8fo00483h, 10.1039/C8FO00483H]
[26]
Bioavailability, bioactivity and impact on health of dietary flavonoids and related compounds: an update [J].
Rodriguez-Mateos, Ana ;
Vauzour, David ;
Krueger, Christian G. ;
Shanmuganayagam, Dhanansayan ;
Reed, Jess ;
Calani, Luca ;
Mena, Pedro ;
Del Rio, Daniele ;
Crozier, Alan .
ARCHIVES OF TOXICOLOGY, 2014, 88 (10) :1803-1853
[27]
Relationship of Arterial Stiffness Index and Pulse Pressure With Cardiovascular Disease and Mortality [J].
Said, M. Abdullah ;
Eppinga, Ruben N. ;
Lipsic, Erik ;
Verweij, Niek ;
van der Harst, Pim .
JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2018, 7 (02)
[28]
Angiotensin II receptor blocker telmisartan attenuates aortic stiffening and remodelling in STZ-diabetic rats [J].
Salum, Erik ;
Butlin, Mark ;
Kals, Jaak ;
Zilmer, Mihkel ;
Eha, Jaan ;
Avolio, Alberto P. ;
Arend, Andres ;
Aunapuu, Marina ;
Kampus, Priit .
DIABETOLOGY & METABOLIC SYNDROME, 2014, 6
[29]
Methylxanthines enhance the effects of cocoa flavanols on cardiovascular function: randomized, double-masked controlled studies [J].
Sansone, Roberto ;
Ottaviani, Javier I. ;
Rodriguez-Mateos, Ana ;
Heinen, Yvonne ;
Noske, Dorina ;
Spencer, Jeremy P. ;
Crozier, Alan ;
Merx, Marc W. ;
Kelm, Malte ;
Schroeter, Hagen ;
Heiss, Christian .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2017, 105 (02) :352-360
[30]
Shah SR, 2017, J COMMUNITY HOSP INT, V7, P218, DOI 10.1080/20009666.2017.1361293