Effect of soluble interleukin-6 receptor on interleukin-6 synthesis in human skin fibroblasts

被引：18

作者：

Cichy, J

RoseJohn, S

Pryjma, J

Travis, J

机构：

[1] UNIV GEORGIA,DEPT BIOCHEM & MOL BIOL,ATHENS,GA 30602

[2] JAGIELLONIAN UNIV,INST MOL BIOL,DEPT MICROBIOL & IMMUNOL,PL-31120 KRAKOW,POLAND

[3] UNIV MAINZ,DEPT MED,D-55101 MAINZ,GERMANY

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1996年 / 227卷 / 02期

关键词：

D O I：

10.1006/bbrc.1996.1507

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this study the ability of soluble interleukin-6 receptor (sIL-6R) to stimulate interleukin-6 (IL-B) synthesis in human fibroblasts is described. It was found that sIL-6R, in combination with endogenous or exogenous IL-6, markedly upregulated IL-6 synthesis. These data suggest that increased IL-6 production after stimulation by either interleukin-l or tumor necrosis factor-alpha would result in complex formation with sIL-6R, rapid uptake, and further synthesis of this cytokine. Furthermore, it would explain the decrease in sIL-6R plasma levels observed in patients suffering, from sepsis. (C) 1996 Academic Press, Inc.

引用

页码：318 / 321

页数：4

共 21 条

[1] THE ACUTE-PHASE RESPONSE
BAUMANN, H
GAULDIE, J
[J]. IMMUNOLOGY TODAY, 1994, 15 (02): : 74 - 80
[2] DONNELLY RP, 1993, J IMMUNOL, V151, P5603
[3] CIRCULATING INTERLEUKIN-6 RECEPTOR IN PATIENTS WITH SEPSIS SYNDROME
FRIELING, JTM
VANDEUREN, M
WIJDENES, J
VANDERMEER, JWM
CLEMENT, C
VANDERLINDEN, CJ
SAUERWEIN, RW
[J]. JOURNAL OF INFECTIOUS DISEASES, 1995, 171 (02) : 469 - 472
[4] B-CELL-STIMULATORY FACTOR-II (BETA-2 INTERFERON) FUNCTIONS AS A 2ND SIGNAL FOR INTERLEUKIN-2 PRODUCTION BY MATURE MURINE T-CELLS
GARMAN, RD
JACOBS, KA
CLARK, SC
RAULET, DH
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (21) : 7629 - 7633
[5] COMPLEMENTARY-DNA FOR A NOVEL HUMAN INTERLEUKIN (BSF-2) THAT INDUCES LYMPHOCYTES-B TO PRODUCE IMMUNOGLOBULIN
HIRANO, T
YASUKAWA, K
HARADA, H
TAGA, T
WATANABE, Y
MATSUDA, T
KASHIWAMURA, S
NAKAJIMA, K
KOYAMA, K
IWAMATSU, A
TSUNASAWA, S
SAKIYAMA, F
MATSUI, H
TAKAHARA, Y
TANIGUCHI, T
KISHIMOTO, T
[J]. NATURE, 1986, 324 (6092) : 73 - 76
[6] INTERLEUKIN-6 FAMILY OF CYTOKINES AND GP130
KISHIMOTO, T
AKIRA, S
NARAZAKI, M
TAGA, T
[J]. BLOOD, 1995, 86 (04) : 1243 - 1254
[7] MACKIEWICZ A, 1992, J IMMUNOL, V149, P2021
[8] PROTEIN-KINASE-C ACTIVITY IS RATE LIMITING FOR SHEDDING OF THE INTERLEUKIN-6 RECEPTOR
MULLBERG, J
SCHOOLTINK, H
STOYAN, T
HEINRICH, PC
ROSEJOHN, S
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 189 (02) : 794 - 800
[9] The function of the soluble interleukin 6 (IL-6) receptor in vivo: Sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half-life of IL-6
Peters, M
Jacobs, S
Ehlers, M
Vollmer, P
Mullberg, J
Wolf, E
Brem, G
zumBuschenfelde, KHM
RoseJohn, S
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 183 (04) : 1399 - 1406
[10] RICHARDS CD, 1993, J IMMUNOL, V150, P5596

← 1 2 3 →