TPGS-chitosan cross-linked targeted nanoparticles for effective brain cancer therapy

被引：85

作者：

Agrawal, Poomima ^{[2
]}

Singh, Rahul Pratap ^{[2
]}

Sonali ^{[2
]}

Kumari, Laksmi ^{[1
]}

Sharma, Gunjan ^{[3
]}

Koch, Biplob ^{[3
]}

Rajesh, Chellapa V. ^{[4
]}

Mehata, Abhishesh K. ^{[1
]}

Singh, Sanjay ^{[1
]}

Pandey, Bajarangprasad L. ^{[2
]}

Muthu, Madaswamy S. ^{[1
,2
]}

机构：

[1] Indian Inst Technol BHU, Dept Pharmaceut, Varanasi 221005, Uttar Pradesh, India

[2] Banaras Hindu Univ, Inst Med Sci, Dept Pharmacol, Varanasi 221005, Uttar Pradesh, India

[3] Banaras Hindu Univ, Inst Sci, Dept Zool, Genotoxicol & Canc Biol Lab, Varanasi 221005, Uttar Pradesh, India

[4] PSG Coll Pharm, Dept Pharmaceut, Coimbatore 641004, Tamil Nadu, India

来源：

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2017年 / 74卷

关键词：

Brain cancer; Transferrin receptor; Targeted nanomedicines; Synergistic effect; Chitosan; TPGS; VITAMIN-E TPGS; THERANOSTIC LIPOSOMES; PLGA NANOPARTICLES; CARBON NANOTUBES; DRUG-DELIVERY; CO-DELIVERY; IN-VITRO; TRANSFERRIN; DOCETAXEL; MICELLES;

D O I：

10.1016/j.msec.2017.02.008

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

082905 [生物质能源与材料]; 100103 [病原生物学];

摘要：

Brain cancer, up-regulated with transferrin receptor led to concept of transferrin receptor targeted anticancer therapeutics. Docetaxel loaded D-alpha-tocopherol polyethylene glycol 1000 succinate conjugated chitosan (TPGS-chitosan) nanoparticles were prepared with or without transferrin decoration. In vitro experiments using C6 glioma cells showed that docetaxel loaded chitosan nanoparticles, non-targeted and transferrin receptor targeted TPGS-chitosan nanoparticles have enhanced the cellular uptake and cytdtoxicity. The IC50 values of non targeted and transferrin receptor targeted nanoparticles from cytotoxic assay were found to be 27 and 148 folds, respectively higher than Docel (TM). In vivo pharmacokinetic study showed 3.23 and 4.10 folds enhancement in relative bioavailability of docetaxel for non-targeted and transferrin receptor targeted nanoparticles, respectively than Docel (TM). The results have demonstrated that transferrin receptor targeted nanoparticles could enhance the cellular internalization and cytotoxicity of docetaxel via transferrin receptor with improved pharmacokinetics for clinical applications. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：167 / 176

页数：10

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