Protein tyrosine kinase Syk in mast cell signaling

被引：122

作者：

Siraganian, RP ^{[1
]}

Zhang, J ^{[1
]}

Suzuki, K ^{[1
]}

Sada, K ^{[1
]}

机构：

[1] NIDCR, Receptors & Signal Transduct Sect, Oral Infect & Immun Branch, NIH, Bethesda, MD 20892 USA

来源：

MOLECULAR IMMUNOLOGY | 2002年 / 38卷 / 16-18期

关键词：

mast cells; protein tyrosine kinase Syk; signal transduction; Fe epsilon RI; histamine release;

D O I：

10.1016/S0161-5890(02)00068-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The tyrosine kinase Syk is essential for signaling from FcepsilonRI in mast cells. The Src homology domain mediated binding of Syk to the phosphorylated immunoreceptor tyrosine-based motif (ITAM) of the receptor subunits results in a conformational change and activation. Studies in Syk deficient mast cells have defined the pathways that are activated upstream and downstream of Syk and have demonstrated the functional importance of the linker region of Syk in signaling in mast cells. Published by Elsevier Science Ltd.

引用

页码：1229 / 1233

页数：5

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