Nanoparticles for two-photon photodynamic therapy in living cells

被引：185

作者：

Gao, De

Agayan, Rodney R.

Xu, Hao

Philbert, Martin A.

Kopelman, Raoul ^{[1
]}

机构：

[1] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Appl Phys, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA

来源：

NANO LETTERS | 2006年 / 6卷 / 11期

关键词：

D O I：

10.1021/nl0617179

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We describe here a nontoxic two-photon photodynamic nanoparticle platform and its cellular application. We demonstrate that the dye's potential toxicity can be circumvented by its permanent encapsulation into a biocompatible nanoparticle polymer matrix; this was examined by dye leaching experiments and confirmed by cell uptake experiments. Infrared two-photon nanoplatform phototoxicity was demonstrated for rat C6 glioma cells, while the controls showed no dark toxicity for these living cells.

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收藏

页码：2383 / 2386

页数：4

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