Regulatory non-coding RNAs: revolutionizing the RNA world

被引：82

作者：

Huang, Biao ^{[1
,2
,3
]}

Zhang, Rongxin ^{[1
,2
,3
]}

机构：

[1] Tianjin Med Univ, Res Ctr Basic Med Sci, Tianjin 300070, Peoples R China

[2] Tianjin Med Univ, Dept Immunol, Basic Med Coll, Tianjin 300070, Peoples R China

[3] Tianjin Med Univ, Tianjin Key Lab Cellular & Mol Immunol, Key Lab Immune Microenvironm & Dis, Educ Minist China, Tianjin 300070, Peoples R China

来源：

MOLECULAR BIOLOGY REPORTS | 2014年 / 41卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Regulatory non-coding RNAs; RNA world; Modes of action; MESSENGER-RNAS; GENE; TRANSCRIPTION; CHROMATIN; TRANSLATION; MICRORNAS; DIFFERENTIATION; REPRESSION; INITIATION; LINCRNAS;

D O I：

10.1007/s11033-014-3259-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The majority of the genomic DNA sequence in mammalian and other higher organisms can be transcribed into abundant functional RNA transcripts, especially regulatory non-coding RNAs (ncRNAs) that are expressed in a developmentally and species-specific regulated manner. Here, we review various regulatory non-coding RNAs, including regulatory small non-coding RNAs (sncRNAs) and long non-coding RNAs (lncRNAs), and summarize two and eight kinds of distinct modes of action for sncRNAs and lncRNAs respectively, by which functional ncRNAs mediate the regulation of intracellular events.

引用

收藏

页码：3915 / 3923

页数：9

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