Regulatory non-coding RNAs: revolutionizing the RNA world

被引:82
作者
Huang, Biao [1 ,2 ,3 ]
Zhang, Rongxin [1 ,2 ,3 ]
机构
[1] Tianjin Med Univ, Res Ctr Basic Med Sci, Tianjin 300070, Peoples R China
[2] Tianjin Med Univ, Dept Immunol, Basic Med Coll, Tianjin 300070, Peoples R China
[3] Tianjin Med Univ, Tianjin Key Lab Cellular & Mol Immunol, Key Lab Immune Microenvironm & Dis, Educ Minist China, Tianjin 300070, Peoples R China
基金
中国国家自然科学基金;
关键词
Regulatory non-coding RNAs; RNA world; Modes of action; MESSENGER-RNAS; GENE; TRANSCRIPTION; CHROMATIN; TRANSLATION; MICRORNAS; DIFFERENTIATION; REPRESSION; INITIATION; LINCRNAS;
D O I
10.1007/s11033-014-3259-6
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
070307 [化学生物学]; 071010 [生物化学与分子生物学];
摘要
The majority of the genomic DNA sequence in mammalian and other higher organisms can be transcribed into abundant functional RNA transcripts, especially regulatory non-coding RNAs (ncRNAs) that are expressed in a developmentally and species-specific regulated manner. Here, we review various regulatory non-coding RNAs, including regulatory small non-coding RNAs (sncRNAs) and long non-coding RNAs (lncRNAs), and summarize two and eight kinds of distinct modes of action for sncRNAs and lncRNAs respectively, by which functional ncRNAs mediate the regulation of intracellular events.
引用
收藏
页码:3915 / 3923
页数:9
相关论文
共 64 条
[1]
Ribosome Profiling Shows That miR-430 Reduces Translation Before Causing mRNA Decay in Zebrafish [J].
Bazzini, Ariel A. ;
Lee, Miler T. ;
Giraldez, Antonio J. .
SCIENCE, 2012, 336 (6078) :233-237
[2]
A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transition [J].
Beltran, Manuel ;
Puig, Isabel ;
Pena, Cristina ;
Miguel Garcia, Jose ;
Belen Alvarez, Ana ;
Pena, Raul ;
Bonilla, Felix ;
Garcia de Herreros, Antonio .
GENES & DEVELOPMENT, 2008, 22 (06) :756-769
[3]
Transcription and RNAi in heterochromatic gene silencing [J].
Buehler, Marc ;
Moazed, Danesh .
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2007, 14 (11) :1041-1048
[4]
A Long ncRNA Links Copy Number Variation to a Polycomb/Trithorax Epigenetic Switch in FSHD Muscular Dystrophy [J].
Cabianca, Daphne S. ;
Casa, Valentina ;
Bodega, Beatrice ;
Xynos, Alexandros ;
Ginelli, Enrico ;
Tanaka, Yujiro ;
Gabellini, Davide .
CELL, 2012, 149 (04) :819-831
[5]
A Long Noncoding RNA Controls Muscle Differentiation by Functioning as a Competing Endogenous RNA [J].
Cesana, Marcella ;
Cacchiarelli, Davide ;
Legnini, Ivano ;
Santini, Tiziana ;
Sthandier, Olga ;
Chinappi, Mauro ;
Tramontano, Anna ;
Bozzoni, Irene .
CELL, 2011, 147 (02) :358-369
[6]
Small RNAs are on the move [J].
Chitwood, Daniel H. ;
Timmermans, Marja C. P. .
NATURE, 2010, 467 (7314) :415-419
[7]
miRNA-Mediated Gene Silencing by Translational Repression Followed by mRNA Deadenylation and Decay [J].
Djuranovic, Sergej ;
Nahvi, Ali ;
Green, Rachel .
SCIENCE, 2012, 336 (6078) :237-240
[8]
Non-coding RNAs in human disease [J].
Esteller, Manel .
NATURE REVIEWS GENETICS, 2011, 12 (12) :861-874
[9]
The Evf-2 noncoding RNA is transcribed from the Dlx-5/6 ultraconserved region and functions as a Dlx-2 transcriptional coactivator [J].
Feng, Jianchi ;
Bi, Chumming ;
Clark, Brian S. ;
Mady, Rina ;
Shah, Palak ;
Kohtz, Jhumku D. .
GENES & DEVELOPMENT, 2006, 20 (11) :1470-1484
[10]
Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? [J].
Filipowicz, Witold ;
Bhattacharyya, Suvendra N. ;
Sonenberg, Nahum .
NATURE REVIEWS GENETICS, 2008, 9 (02) :102-114