Elevated calcitonin precursor levels are related to mortality in an animal model of sepsis

被引:45
作者
Steinwald, PM
Whang, KT
Becker, KL
Snider, RH
Nylen, ES
White, JC
机构
[1] Vet Affairs Med Ctr, Dept Surg, Washington, DC 20422 USA
[2] George Washington Univ, Med Ctr, Washington, DC 20037 USA
[3] Georgetown Univ, Med Ctr, Washington, DC 20007 USA
[4] Vet Affairs Med Ctr, Endocrinol Sect, Washington, DC 20422 USA
[5] George Washington Univ, Med Ctr, Washington, DC 20422 USA
来源
CRITICAL CARE | 1999年 / 3卷 / 01期
关键词
inflammation; peritonitis; procalcitonin; prohormone; serum marker;
D O I
10.1186/cc300
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Background: Increased serum levels of procalcitonin (ProCT) and its component peptides have been reported in humans with sepsis. Using a hamster model of bacterial peritonitis, we investigated whether serum ProCT levels are elevated and correlate with mortality and hypocalcemia. Results: Incremental increases in doses of bacteria resulted in proportional increases in 72 h mortality rates (0, 20, 70, and 100%) as well as increases in serum total immunoreactive calcitonin (iCT) levels at 12 h (250, 380, 1960, and 4020 pg/ml, respectively, vs control levels of 21 pg/ml). Gel filtration studies revealed that ProCT was the predominant (>90%) molecular form of serum iCT secreted. In the metabolic experiments, total iCT peaked at 12 h concurrent with the maximal decrease in serum calcium. Conclusions: In this animal model, hyper-procalcitoninemia was an early systemic marker of sepsis which correlated closely with mortality and had an inverse correlation with serum calcium levels.
引用
收藏
页码:11 / 16
页数:6
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