New prototypical O-linked-glycopeptidomimetics corresponding to the linkage region of proteoglycans

被引：23

作者：

Kim, JM ^{[1
]}

Roy, R ^{[1
]}

机构：

[1] UNIV OTTAWA,DEPT CHEM,OTTAWA,ON K1N 6N5,CANADA

来源：

CARBOHYDRATE RESEARCH | 1997年 / 298卷 / 03期

关键词：

D-xylose; oligoglycine; peptoid; peptidomimetic; proteoglycan;

D O I：

10.1016/S0008-6215(96)00301-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new class of glycopeptidomimetic composed of N-substituted oligoglycine (peptoid) mimicking the beta-D-Xyl-(1 --> 3)-O-L-Ser linkage region of proteoglycans was synthesized using a convergent approach. Reiterative N-alkylation-N-bromoacetylation reactions were used starting from tert-butyl bromoacetate (1) and isopropylamine. Perbenzoylated 2-aminoethyl beta-D-xylopyranoside 10 constituted the key glycan L-Ser mimic. (C) 1997 Elsevier Science Ltd.

引用

页码：173 / 179

页数：7

共 17 条

[1] SYNTHESIS OF GLYCURONAMIDES OF AMINO-ACIDS, CONSTITUENTS OF MICROBIAL POLYSACCHARIDES AND THEIR CONVERSION INTO NEOGLYCOCONJUGATES OF COPOLYMER TYPE [J].