Complement-modulating properties of a kaempferol 7-O-rhamnosylsophoroside from the leaves of Morinda morindoides

被引：31

作者：

Cimanga, K ^{[1
]}

deBruyne, T ^{[1
]}

VanPoel, B ^{[1
]}

Ma, YL ^{[1
]}

Claeys, M ^{[1
]}

Pieters, L ^{[1
]}

Kambu, K ^{[1
]}

Tona, L ^{[1
]}

Bakana, P ^{[1
]}

Vanden Berghe, D ^{[1
]}

Vlietinck, AJ ^{[1
]}

机构：

[1] UNIV KINSHASA, FAC PHARM, KINSHASA 11, DEM REP CONGO

来源：

PLANTA MEDICA | 1997年 / 63卷 / 03期

关键词：

Morinda morindoides; rubiaceae; flavonol; kaempferol; 7-O-rhamnosylsophoroside; complement-modulating properties;

D O I：

10.1055/s-2006-957657

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A kaempferol 7-O-rhamnosylsophoroside isolated from the leaves of Morinda morindoides showed dose-dependent complement-modulating properties towards both the classical (inhibiting effect) and alternative (activating effect) pathways of the complement system. Its structure was elucidated by chemical and spectroscopic methods as kaempferol 7-O-[alpha-L-rhamnopyranosyl-(1 --> 6)]-[beta-D-glucopyranosyl-(1 --> 2)]-beta-D-glucopyranoside, a new natural product which was named morindaoside.

引用

页码：220 / 223

页数：4

共 20 条

[1]

ADEWUNMI C O, 1984, Fitoterapia, V55, P259

[2]

Agrawal P.K., 1989, CARBON 13 NMR FLAVON, P283

[3] KAEMPFEROL GLYCOSIDES FROM HOSTA-VENTRICOSA [J].

BUDZIANOWSKI, J .

PHYTOCHEMISTRY, 1990, 29 (11) :3643-3647

[4] ANTI-TUMOR AGENTS .50. MORINDAPARVIN-A, A NEW ANTILEUKEMIC ANTHRAQUINONE, AND ALIZARIN-1-METHYL ETHER FROM MORINDA-PARVIFOLIA, AND THE ANTILEUKEMIC ACTIVITY OF THE RELATED DERIVATIVES [J].

CHANG, P ;

LEE, KH ;

SHINGU, T ;

HIRAYAMA, T ;

HALL, IH ;

HUANG, HC .

JOURNAL OF NATURAL PRODUCTS, 1982, 45 (02) :206-210

[5] ANTITUMOR AGENTS .67. CYTO-TOXIC ANTILEUKEMIC ANTHRAQUINONES FROM MORINDA-PARVIFOLIA [J].

CHANG, P ;

LEE, KH .

PHYTOCHEMISTRY, 1984, 23 (08) :1733-1736

[6] FLAVONOID O-GLYCOSIDES FROM THE LEAVES OF MORINDA MORINDOIDES [J].

CIMANGA, K ;

DEBRUYNE, T ;

LASURE, A ;

LI, QM ;

PIETERS, L ;

CLAEYS, M ;

VANDENBERGHE, D ;

KAMBU, K ;

TONA, L ;

VLIETINCK, A .

PHYTOCHEMISTRY, 1995, 38 (05) :1301-1303

[7] IN-VITRO ANTICOMPLEMENTARY ACTIVITY OF CONSTITUENTS FROM MORINDA MORINDOIDES [J].

CIMANGA, K ;

DEBRUYNE, T ;

LASURE, A ;

VANPOEL, B ;

PIETERS, L ;

VANDENBERGHE, D ;

VLIETINCK, A ;

KAMBU, K ;

TONA, L .

JOURNAL OF NATURAL PRODUCTS-LLOYDIA, 1995, 58 (03) :372-378

[8]

KAMBU K, 1990, PHYTOTHERAPIE COMPAR

[9]

Kerharo J, 1974, PHARM TRADITIONNELLE

[10] EFFECTS OF 3 COMPOUNDS EXTRACTED FROM MORINDA-LUCIDA ON PLASMODIUM-FALCIPARUM [J].

KOUMAGLO, K ;

GBEASSOR, M ;

NIKABU, O ;

DESOUZA, C ;

WERNER, W .

PLANTA MEDICA, 1992, 58 (06) :533-534

← 1 2 →