Covalent binding of catechols to Src family SH2 domains

被引：10

作者：

Jagoe, CT

Kreifels, SE

Li, JM

机构：

[1] Oncology Research Program, Sandoz Research Institute, Sandoz Pharmaceuticals Corporation, East Hanover

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(96)00589-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Src family SH2 domains contain an uncoupled cysteine residue, that, when arylated with air oxidized catechols, inhibits the protein from binding to otherwise high affinity peptide ligands. No inhibition is observed for Crk, Abl, or Grb2 SH2 domains. (C) 1997, Elsevier Science Ltd.

引用

页码：113 / 116

页数：4

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