Primary structure and expression of a naturally truncated human P2X ATP receptor subunit from brain and immune system

被引：71

作者：

Le, KT ^{[1
]}

Paquet, M ^{[1
]}

Nouel, D ^{[1
]}

Babinski, K ^{[1
]}

Seguela, P ^{[1
]}

机构：

[1] MCGILL UNIV,MONTREAL NEUROL INST,CELL BIOL EXCITABLE TISSUE GRP,MONTREAL,PQ H3A 2B4,CANADA

来源：

FEBS LETTERS | 1997年 / 418卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

transmitter-gated channel; purinoceptor; nucleotide; lymphocyte; cerebellum;

D O I：

10.1016/S0014-5793(97)01380-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel member of the ionotropic ATP receptor gene family has been identified in human brain. This 422 amino acid long P2X receptor subunit has 62% sequence identity with rat P2X(5). Several characteristic motifs of ATP-gated channels are present in its primary structure, but this P2X(5)-related subunit displays a single transmembrane domain, Heterologous expression of chimeric subunits containing the C-terminal domain of rat P2X(5) leads to the formation of desensitizing functional ATP-gated channels in Xenopus oocytes, The developmentally regulated mRNA, found in two splicing variant forms, is expressed at high levels in brain and immune system. (C) 1997 Federation of European Biochemical Societies.

引用

页码：195 / 199

页数：5

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