Polymers as biomaterials for tissue engineering and controlled drug delivery

被引：339

作者：

Nair, Lakshmi S.

Laurencin, Cato T. ^{[1
]}

机构：

[1] Univ Virginia, Dept Biomed Engn, Charlottesville, VA 22908 USA

[2] Univ Virginia, Coll Med, Dept Orthopaed Surg, Charlottesville, VA 22903 USA

[3] Univ Virginia, Dept Chem Engn, Charlottesville, VA 22904 USA

来源：

TISSUE ENGINEERING I: SCAFFOLD SYSTEMS FOR TISSUE ENGINEERING | 2006年 / 102卷

关键词：

biodegradable polymers; drug delivery; polymeric biomaterials; tissue engineering;

D O I：

10.1007/b137240

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The advent of biodegradable polymers has significantly influenced the development and rapid growth of various technologies in modern medicine. Biodegradable polymers are mainly used where the transient existence of materials is required and they find applications as sutures, scaffolds for tissue regeneration, tissue adhesives, hemostats, and transient barriers for tissue adhesion, as well as drug delivery systems. Each of these applications demands materials with unique physical, chemical, biological, and biomechanical properties to provide efficient therapy. Consequently, a wide range of degradable polymers, both natural and synthetic, have been investigated for these applications. Furthermore, recent advances in molecular and cellular biology, coupled with the development of novel biotechnological drugs, necessitate the modification of existing polymers or synthesis of novel polymers for specific applications. This review highlights various biodegradable polymeric materials currently investigated for use in two key medical applications: drug delivery and tissue engineering.

引用

页码：47 / 90

页数：44

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[41] OSTEOBLAST-LIKE CELL (MC3T3-E1) PROLIFERATION ON BIOERODIBLE POLYMERS - AN APPROACH TOWARDS THE DEVELOPMENT OF A BONE BIOERODIBLE POLYMER COMPOSITE-MATERIAL [J].