Mosquito transgenesis: what is the fitness cost?

被引：109

作者：

Marrelli, Mauro T.

Moreira, Cristina K.

Kelly, David

Alphey, Luke

Jacobs-Lorena, Marcelo

机构：

[1] Johns Hopkins Univ, Bloomberg Sch Publ HLth, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA

[2] Malaria Res Inst, Baltimore, MD 21205 USA

[3] Univ Oxford, Dept Zool, Oxford OX1 3PS, England

[4] Oxitec Ltd, Oxford OX14 4RX, England

来源：

TRENDS IN PARASITOLOGY | 2006年 / 22卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.pt.2006.03.004

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The generation of transgenic mosquitoes with a minimal fitness load is a prerequisite for the success of strategies for controlling mosquito-borne diseases using transgenic insects. It is important to assemble as much information as possible on this subject because realistic estimates of transgene fitness costs are essential for modeling and planning release strategies. Transgenic mosquitoes must have minimal fitness costs, because such costs would reduce the effectiveness of the genetic drive mechanisms that are used to introduce the transgenes into field mosquito populations. Several factors affect fitness of transgenic mosquitoes, including the potential negative effect of transgene products and insertional mutagenesis. Studies to assess fitness of transgenic mosquitoes in the field (as opposed to the laboratory) are still needed.

引用

页码：197 / 202

页数：6

共 49 条

[31] An anti-chitinase malaria transmission-blocking single-chain antibody as an effector molecule for creating a Plasmodium falciparum-refractory mosquito [J].