Chemoenzymic synthesis of P-alpha-methyl deoxynucleoside triphosphates

被引：7

作者：

Dineva, MA ^{[1
]}

Petkov, DD ^{[1
]}

机构：

[1] BULGARIAN ACAD SCI,INST ORGAN CHEM,LAB BIOCATALYSIS,SOFIA 1113,BULGARIA

来源：

NUCLEOSIDES & NUCLEOTIDES | 1996年 / 15卷 / 09期

关键词：

D O I：

10.1080/07328319608002447

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

5'-O-(methylphosphonyl)-N-(phenylacetyl)-2'-deoxycytidine, deoxyadenosine and deoxyguanosine were pyrophosphorylated and the resulting N-protected P-alpha-methyl nucleoside triphosphates were deblocked by treatment with penicillin amidase at pH 7.8, 25 degrees C to give P-alpha-methyl nucleoside triphosphates.

引用

页码：1459 / 1467

页数：9

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