共 47 条
Adiponectin increases fatty acid oxidation in skeletal muscle cells by sequential activation of AMP-activated protein kinase, p38 mitogen-activated protein kinase, and peroxisome proliferator-activated receptor α
被引:456
作者:

Yoon, Myeong Jin
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机构: Seoul Natl Univ, Res Ctr Funct Cellulom, Dept Biol Sci, Lab Adipocyte & Metab Res, Seoul 151742, South Korea

Lee, Gha Young
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h-index: 0
机构: Seoul Natl Univ, Res Ctr Funct Cellulom, Dept Biol Sci, Lab Adipocyte & Metab Res, Seoul 151742, South Korea

Chung, Jun-Jae
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机构: Seoul Natl Univ, Res Ctr Funct Cellulom, Dept Biol Sci, Lab Adipocyte & Metab Res, Seoul 151742, South Korea

Ahn, Young Ho
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机构: Seoul Natl Univ, Res Ctr Funct Cellulom, Dept Biol Sci, Lab Adipocyte & Metab Res, Seoul 151742, South Korea

Hong, Seung Hwan
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机构: Seoul Natl Univ, Res Ctr Funct Cellulom, Dept Biol Sci, Lab Adipocyte & Metab Res, Seoul 151742, South Korea

Kim, Jae Bum
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h-index: 0
机构: Seoul Natl Univ, Res Ctr Funct Cellulom, Dept Biol Sci, Lab Adipocyte & Metab Res, Seoul 151742, South Korea
机构:
[1] Seoul Natl Univ, Res Ctr Funct Cellulom, Dept Biol Sci, Lab Adipocyte & Metab Res, Seoul 151742, South Korea
[2] Seoul Natl Univ, Dept Biol Sci, Cell Biol Lab, Seoul 151, South Korea
来源:
关键词:
ADIPOSE-SPECIFIC PROTEIN;
INSULIN SENSITIVITY;
PPAR-ALPHA;
GLUCOSE-TRANSPORT;
METABOLIC STRESS;
DEFICIENT MICE;
MALONYL-COA;
GENE;
OBESITY;
PLASMA;
D O I:
10.2337/db05-1322
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Adiponectin has recently received a great deal of attention due to its beneficial effects on insulin resistance and metabolic disorders. One of the mechanisms through which adiponectin exerts such effects involves an increase in fatty acid oxidation in muscle and liver. In the present study, we demonstrate that W-AMP-activated protein kinase (AMPK) and p38 mitogen-activated protein kinase (MAPK) are involved in the activation of peroxisome proliferator-activated receptor (PPAR)alpha by adiponectin in muscle cells. Adiponectin increases the transcriptional activity of PPAR alpha and the expression of its target genes, including ACO, CPT1, and FABP3 in C2C12 myotubes. These effects were suppressed by the overexpression of a dominant-negative form of AMPK. Moreover, chemical inhibitors of AMPK and p38 MAPK potently repressed fatty acid oxidation and the induction of PPAR alpha target gene expression by adiponectin. Interestingly, araA, an AMPK inhibitor, prevented the activation of p38 MAPK, whereas SB203580, a p38 MAPK inhibitor, did not affect AMPK activation, suggesting that p38 MAPK is a downstream signaling factor of AMPK. Taken together, these results suggest that adiponectin stimulates fatty acid oxidation in muscle cells by the sequential activation of AMPK, p38 MAPK, and PPAR alpha.
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页码:2562 / 2570
页数:9
相关论文
共 47 条
[1]
Malonyl-CoA and the regulation of fatty acid oxidation in soleus muscle
[J].
Alam, N
;
Saggerson, ED
.
BIOCHEMICAL JOURNAL,
1998, 334
:233-241

Alam, N
论文数: 0 引用数: 0
h-index: 0
机构:
Univ London Univ Coll, Dept Biochem & Mol Biol, London WC1E 6BT, England Univ London Univ Coll, Dept Biochem & Mol Biol, London WC1E 6BT, England

Saggerson, ED
论文数: 0 引用数: 0
h-index: 0
机构:
Univ London Univ Coll, Dept Biochem & Mol Biol, London WC1E 6BT, England Univ London Univ Coll, Dept Biochem & Mol Biol, London WC1E 6BT, England
[2]
Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity
[J].
Arita, Y
;
Kihara, S
;
Ouchi, N
;
Takahashi, M
;
Maeda, K
;
Miyagawa, J
;
Hotta, K
;
Shimomura, I
;
Nakamura, T
;
Miyaoka, K
;
Kuriyama, H
;
Nishida, M
;
Yamashita, S
;
Okubo, K
;
Matsubara, K
;
Muraguchi, M
;
Ohmoto, Y
;
Funahashi, T
;
Matsuzawa, Y
.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,
1999, 257 (01)
:79-83

Arita, Y
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Grad Sch Med, Dept Internal Med & Mol Sci, Suita, Osaka 5650871, Japan

Kihara, S
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Grad Sch Med, Dept Internal Med & Mol Sci, Suita, Osaka 5650871, Japan

Ouchi, N
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Grad Sch Med, Dept Internal Med & Mol Sci, Suita, Osaka 5650871, Japan

Takahashi, M
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Grad Sch Med, Dept Internal Med & Mol Sci, Suita, Osaka 5650871, Japan

Maeda, K
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Grad Sch Med, Dept Internal Med & Mol Sci, Suita, Osaka 5650871, Japan

Miyagawa, J
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Grad Sch Med, Dept Internal Med & Mol Sci, Suita, Osaka 5650871, Japan

Hotta, K
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Grad Sch Med, Dept Internal Med & Mol Sci, Suita, Osaka 5650871, Japan

Shimomura, I
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Grad Sch Med, Dept Internal Med & Mol Sci, Suita, Osaka 5650871, Japan

Nakamura, T
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Grad Sch Med, Dept Internal Med & Mol Sci, Suita, Osaka 5650871, Japan

Miyaoka, K
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Grad Sch Med, Dept Internal Med & Mol Sci, Suita, Osaka 5650871, Japan

Kuriyama, H
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Grad Sch Med, Dept Internal Med & Mol Sci, Suita, Osaka 5650871, Japan

Nishida, M
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Grad Sch Med, Dept Internal Med & Mol Sci, Suita, Osaka 5650871, Japan

Yamashita, S
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Grad Sch Med, Dept Internal Med & Mol Sci, Suita, Osaka 5650871, Japan

Okubo, K
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Grad Sch Med, Dept Internal Med & Mol Sci, Suita, Osaka 5650871, Japan

Matsubara, K
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Grad Sch Med, Dept Internal Med & Mol Sci, Suita, Osaka 5650871, Japan

Muraguchi, M
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Grad Sch Med, Dept Internal Med & Mol Sci, Suita, Osaka 5650871, Japan

Ohmoto, Y
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Grad Sch Med, Dept Internal Med & Mol Sci, Suita, Osaka 5650871, Japan

Funahashi, T
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Grad Sch Med, Dept Internal Med & Mol Sci, Suita, Osaka 5650871, Japan

Matsuzawa, Y
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Grad Sch Med, Dept Internal Med & Mol Sci, Suita, Osaka 5650871, Japan
[3]
p38 mitogen-activated protein kinase activates peroxisome proliferator-activated receptor α -: A potential role in the cardiac metabolic stress response
[J].
Barger, PM
;
Browning, AC
;
Garner, AN
;
Kelly, DP
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
2001, 276 (48)
:44495-44501

Barger, PM
论文数: 0 引用数: 0
h-index: 0
机构: Washington Univ, Sch Med, Cardiovasc Res Ctr, Dept Med, St Louis, MO 63110 USA

Browning, AC
论文数: 0 引用数: 0
h-index: 0
机构: Washington Univ, Sch Med, Cardiovasc Res Ctr, Dept Med, St Louis, MO 63110 USA

Garner, AN
论文数: 0 引用数: 0
h-index: 0
机构: Washington Univ, Sch Med, Cardiovasc Res Ctr, Dept Med, St Louis, MO 63110 USA

Kelly, DP
论文数: 0 引用数: 0
h-index: 0
机构: Washington Univ, Sch Med, Cardiovasc Res Ctr, Dept Med, St Louis, MO 63110 USA
[4]
The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
[J].
Berg, AH
;
Combs, TP
;
Du, XL
;
Brownlee, M
;
Scherer, PE
.
NATURE MEDICINE,
2001, 7 (08)
:947-953

Berg, AH
论文数: 0 引用数: 0
h-index: 0
机构: Albert Einstein Coll Med, Dept Cell Biol, Bronx, NY 10467 USA

Combs, TP
论文数: 0 引用数: 0
h-index: 0
机构: Albert Einstein Coll Med, Dept Cell Biol, Bronx, NY 10467 USA

Du, XL
论文数: 0 引用数: 0
h-index: 0
机构: Albert Einstein Coll Med, Dept Cell Biol, Bronx, NY 10467 USA

Brownlee, M
论文数: 0 引用数: 0
h-index: 0
机构: Albert Einstein Coll Med, Dept Cell Biol, Bronx, NY 10467 USA

Scherer, PE
论文数: 0 引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med, Dept Cell Biol, Bronx, NY 10467 USA Albert Einstein Coll Med, Dept Cell Biol, Bronx, NY 10467 USA
[5]
Effect of 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside infusion on in vivo glucose and lipid metabolism in lean and obese Zucker rats
[J].
Bergeron, R
;
Previs, SF
;
Cline, GW
;
Perret, P
;
Russell, RR
;
Young, LH
;
Shulman, GI
.
DIABETES,
2001, 50 (05)
:1076-1082

Bergeron, R
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06510 USA

Previs, SF
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06510 USA

Cline, GW
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06510 USA

Perret, P
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06510 USA

Russell, RR
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06510 USA

Young, LH
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06510 USA

Shulman, GI
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06510 USA
[6]
Long-term AICAR administration reduces metabolic disturbances and lowers blood pressure in rats displaying features of the insulin resistance syndrome
[J].
Buhl, ES
;
Jessen, N
;
Pold, R
;
Ledet, T
;
Flyvbjerg, A
;
Pedersen, SB
;
Pedersen, O
;
Schmitz, O
;
Lund, S
.
DIABETES,
2002, 51 (07)
:2199-2206

Buhl, ES
论文数: 0 引用数: 0
h-index: 0
机构: Aarhus Univ Hosp, Med Dept M Endocrinol & Diabet, Aarhus Kommune Hosp, DK-8000 Aarhus C, Denmark

Jessen, N
论文数: 0 引用数: 0
h-index: 0
机构: Aarhus Univ Hosp, Med Dept M Endocrinol & Diabet, Aarhus Kommune Hosp, DK-8000 Aarhus C, Denmark

Pold, R
论文数: 0 引用数: 0
h-index: 0
机构: Aarhus Univ Hosp, Med Dept M Endocrinol & Diabet, Aarhus Kommune Hosp, DK-8000 Aarhus C, Denmark

Ledet, T
论文数: 0 引用数: 0
h-index: 0
机构: Aarhus Univ Hosp, Med Dept M Endocrinol & Diabet, Aarhus Kommune Hosp, DK-8000 Aarhus C, Denmark

Flyvbjerg, A
论文数: 0 引用数: 0
h-index: 0
机构: Aarhus Univ Hosp, Med Dept M Endocrinol & Diabet, Aarhus Kommune Hosp, DK-8000 Aarhus C, Denmark

Pedersen, SB
论文数: 0 引用数: 0
h-index: 0
机构: Aarhus Univ Hosp, Med Dept M Endocrinol & Diabet, Aarhus Kommune Hosp, DK-8000 Aarhus C, Denmark

Pedersen, O
论文数: 0 引用数: 0
h-index: 0
机构: Aarhus Univ Hosp, Med Dept M Endocrinol & Diabet, Aarhus Kommune Hosp, DK-8000 Aarhus C, Denmark

Schmitz, O
论文数: 0 引用数: 0
h-index: 0
机构: Aarhus Univ Hosp, Med Dept M Endocrinol & Diabet, Aarhus Kommune Hosp, DK-8000 Aarhus C, Denmark

Lund, S
论文数: 0 引用数: 0
h-index: 0
机构:
Aarhus Univ Hosp, Med Dept M Endocrinol & Diabet, Aarhus Kommune Hosp, DK-8000 Aarhus C, Denmark Aarhus Univ Hosp, Med Dept M Endocrinol & Diabet, Aarhus Kommune Hosp, DK-8000 Aarhus C, Denmark
[7]
Bezafibrate reduces mRNA levels of adipocyte markers and increases fatty acid oxidation in primary culture of adipocytes
[J].
Cabrero, A
;
Alegret, M
;
Sánchez, RM
;
Adzet, T
;
Laguna, JC
;
Vázquez, M
.
DIABETES,
2001, 50 (08)
:1883-1890

Cabrero, A
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Barcelona, Fac Farm, Dept Pharmacol & Therapeut Chem, Pharmacol Unit, E-08028 Barcelona, Spain Univ Barcelona, Fac Farm, Dept Pharmacol & Therapeut Chem, Pharmacol Unit, E-08028 Barcelona, Spain

Alegret, M
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Barcelona, Fac Farm, Dept Pharmacol & Therapeut Chem, Pharmacol Unit, E-08028 Barcelona, Spain Univ Barcelona, Fac Farm, Dept Pharmacol & Therapeut Chem, Pharmacol Unit, E-08028 Barcelona, Spain

Sánchez, RM
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Barcelona, Fac Farm, Dept Pharmacol & Therapeut Chem, Pharmacol Unit, E-08028 Barcelona, Spain Univ Barcelona, Fac Farm, Dept Pharmacol & Therapeut Chem, Pharmacol Unit, E-08028 Barcelona, Spain

Adzet, T
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Barcelona, Fac Farm, Dept Pharmacol & Therapeut Chem, Pharmacol Unit, E-08028 Barcelona, Spain Univ Barcelona, Fac Farm, Dept Pharmacol & Therapeut Chem, Pharmacol Unit, E-08028 Barcelona, Spain

Laguna, JC
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Barcelona, Fac Farm, Dept Pharmacol & Therapeut Chem, Pharmacol Unit, E-08028 Barcelona, Spain Univ Barcelona, Fac Farm, Dept Pharmacol & Therapeut Chem, Pharmacol Unit, E-08028 Barcelona, Spain

Vázquez, M
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Barcelona, Fac Farm, Dept Pharmacol & Therapeut Chem, Pharmacol Unit, E-08028 Barcelona, Spain Univ Barcelona, Fac Farm, Dept Pharmacol & Therapeut Chem, Pharmacol Unit, E-08028 Barcelona, Spain
[8]
The AMP-activated protein kinase cascade - a unifying system for energy control
[J].
Carling, D
.
TRENDS IN BIOCHEMICAL SCIENCES,
2004, 29 (01)
:18-24

Carling, D
论文数: 0 引用数: 0
h-index: 0
机构:
Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, MRC, Ctr Clin Sci,Cellular Stress Grp, London W12 0NN, England Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, MRC, Ctr Clin Sci,Cellular Stress Grp, London W12 0NN, England
[9]
Rat PPARs: Quantitative analysis in adult rat tissues and regulation in fasting and refeeding
[J].
Escher, P
;
Braissant, O
;
Basu-Modak, S
;
Michalik, L
;
Wahli, W
;
Desvergne, B
.
ENDOCRINOLOGY,
2001, 142 (10)
:4195-4202

Escher, P
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Lausanne, Inst Biol Anim, CH-1015 Lausanne, Switzerland Univ Lausanne, Inst Biol Anim, CH-1015 Lausanne, Switzerland

Braissant, O
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Lausanne, Inst Biol Anim, CH-1015 Lausanne, Switzerland Univ Lausanne, Inst Biol Anim, CH-1015 Lausanne, Switzerland

Basu-Modak, S
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Lausanne, Inst Biol Anim, CH-1015 Lausanne, Switzerland Univ Lausanne, Inst Biol Anim, CH-1015 Lausanne, Switzerland

Michalik, L
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Lausanne, Inst Biol Anim, CH-1015 Lausanne, Switzerland Univ Lausanne, Inst Biol Anim, CH-1015 Lausanne, Switzerland

Wahli, W
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Lausanne, Inst Biol Anim, CH-1015 Lausanne, Switzerland Univ Lausanne, Inst Biol Anim, CH-1015 Lausanne, Switzerland

论文数: 引用数:
h-index:
机构:
[10]
Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice
[J].
Fruebis, J
;
Tsao, TS
;
Javorschi, S
;
Ebbets-Reed, D
;
Erickson, MRS
;
Yen, FT
;
Bihain, BE
;
Lodish, HF
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2001, 98 (04)
:2005-2010

Fruebis, J
论文数: 0 引用数: 0
h-index: 0
机构: Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

Tsao, TS
论文数: 0 引用数: 0
h-index: 0
机构: Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

Javorschi, S
论文数: 0 引用数: 0
h-index: 0
机构: Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

Ebbets-Reed, D
论文数: 0 引用数: 0
h-index: 0
机构: Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

Erickson, MRS
论文数: 0 引用数: 0
h-index: 0
机构: Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

Yen, FT
论文数: 0 引用数: 0
h-index: 0
机构: Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

Bihain, BE
论文数: 0 引用数: 0
h-index: 0
机构: Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

Lodish, HF
论文数: 0 引用数: 0
h-index: 0
机构: Whitehead Inst Biomed Res, Cambridge, MA 02142 USA