Adipopharmacology, a novel drug discovery approach: A metabotrophic perspective

被引：8

作者：

Chaldakov, G. N. ^{[1
]}

Fiore, M.

Tonchev, A. B.

Aloe, L.

机构：

[1] Med Univ, Div Cell Biol, BG-9002 Varna, Bulgaria

[2] CNR, European Brain Res Inst, Inst Neurobiol & Mol Med, NGF Sect, I-00143 Rome, Italy

来源：

LETTERS IN DRUG DESIGN & DISCOVERY | 2006年 / 3卷 / 07期

关键词：

adipobiology; BDNF; CNTF; metallothioneins; metabotrophins; NGF;

D O I：

10.2174/157018006778194835

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Adipopharmacology connotes the adipotargeting studies aimed at drug discovery. Here we focus on adipopharmacology of nerve growth factor, brain-derived neurotrophic factor, ciliary neurotrophic factor and metallothioneins. Because these factors improve glucose, lipid and antioxidant metabolism, we named them metabotrophic factors (metabotrophins).

引用

页码：503 / 505

页数：3

共 58 条

[1]

ALOE L, 2004, NGF RELATED MOL HLTH, P146

[2] Neurotrophins and depression [J].

Altar, CA .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1999, 20 (02) :59-61

[3] Drugs on the horizon for diabesity [J].

Bailey C.J. .

Current Diabetes Reports, 2005, 5 (5) :353-359

[4] Ciliary neurotrophic factor AX15 alters energy homeostasis, decreases body weight, and improves metabolic control in diet-induced obese and UCP1-DTA mice [J].

Blüher, S ;

Moschos, S ;

Bullen, J ;

Kokkotou, E ;

Maratos-Flier, E ;

Wiegand, SJ ;

Sleemann, MW ;

Mantzoros, CS .

DIABETES, 2004, 53 (11) :2787-2796

[5] Adipose targets for obesity drug development [J].

Boss, O ;

Bergenhem, N .

EXPERT OPINION ON THERAPEUTIC TARGETS, 2006, 10 (01) :119-134

[6] Stimulation of NGF expression and secretion in 3T3-L1 adipocytes by prostaglandins PGD2, PGJ2, and Δ12-PGJ2 [J].

Bulló, M ;

Peeraully, MR ;

Trayhurn, P .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2005, 289 (01) :E62-E67

[7] Neurotrophin presence in human coronary atherosclerosis and metabolic syndrome: a role for NGF and BDNF in cardiovascular disease? [J].

Chaldakov, GN ;

Fiore, M ;

Stankulov, IS ;

Manni, L ;

Hristova, MG ;

Antonelli, A ;

Ghenev, PI ;

Aloe, L .

NGF AND RELATED MOLECULES IN HEALTH AND DISEASE, 2004, 146 :279-289

[8] Adipobiology of disease: Adipokines and adipokine-targeted pharmacology [J].

Chaldakov, GN ;

Stankulov, IS ;

Hristova, M ;

Ghenev, PI .

CURRENT PHARMACEUTICAL DESIGN, 2003, 9 (12) :1023-1031

[9]

CHALDAKOV GN, 2003, MED SCI MONITOR, V21, pH19

[10] An integrated functional genomics screening program reveals a role for BMP-9 in glucose homeostasis [J].

Chen, C ;

Grzegorzewski, KJ ;

Barash, S ;

Zhao, QH ;

Schneider, H ;

Singh, M ;

Pukac, L ;

Bell, AC ;

Duan, R ;

Coleman, T ;

Duttaroy, A ;

Cheng, S ;

Hirsch, J ;

Zhang, LY ;

Lazard, Y ;

Fischer, C ;

Barber, MC ;

Ma, ZD ;

Zhang, YQ ;

Reavey, P ;

Zhong, LL ;

Teng, BQ ;

Sanyal, I ;

Ruben, SM ;

Blondel, O ;

Birse, CE .

NATURE BIOTECHNOLOGY, 2003, 21 (03) :294-301

← 1 2 3 4 5 6 →