Structure and expression of two highly related genes encoding SCM-1 human lymphotactin

被引：57

作者：

Yoshida, T ^{[1
]}

Imai, T ^{[1
]}

Takagi, S ^{[1
]}

Nishimura, M ^{[1
]}

Ishikawa, I ^{[1
]}

Yaoi, T ^{[1
]}

Yoshie, O ^{[1
]}

机构：

[1] SHIONOGI INST MED SCI,SETTSU,OSAKA 566,JAPAN

来源：

FEBS LETTERS | 1996年 / 395卷 / 01期

关键词：

chemokine; gene duplication; chromosome mapping; gene expression; transcriptional initiation site;

D O I：

10.1016/0014-5793(96)01004-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

SCM-1/lymphotactin is a chemokine-like molecule produced selectively, if not exclusively, by activated CD8(+) T cells. Here we report that there are two highly homologous SCM-1 genes, which we designate as SCM-1 alpha and SCM-1 beta. Both genes have three exons and two introns. The 1st intron of SCM-1 alpha contains a pseudogene of the ribosomal large subunit L7a. In SCM-1 beta, a 1.5-kb region including about a quarter of the L7a pseudogene is deleted from the 1st intron, Otherwise, the two genes are highly homologous including the 5' and 3' flanking regions, Both genes were mapped to human chromosome 1q23, The two genes were similarly induced in peripheral blood mononuclear cells by mitogenic stimulation, Primer extension and RNase protection revealed several transcription initiation sites, The biological activities of SCM-1 alpha and SCM-1 beta, which hare two amino acid differences at positions 7 and 8 in the mature proteins, remain to be compared.

引用

页码：82 / 88

页数：7

共 21 条

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