Epidemiological studies on ageing in France:: from PAQUID to the Three-City study.

被引:25
作者
Alpérovitch, A
Amouyel, P
Dartigues, JF
Ducimetière, P
Mazoyer, B
Ritchie, K
Tzourio, C
机构
[1] Hop La Pitie Salpetriere, INSERM, U360, F-75651 Paris 13, France
[2] Inst Pasteur, INSERM, U508, F-59019 Lille, France
[3] Univ Victor Segalen, INSERM, U330, F-33076 Bordeaux, France
[4] INSERM, U258, F-94807 Villejuif, France
[5] GIP Cyceron, CNRS, CEA, URM 6095, F-14074 Caen, France
[6] Hop Colombiere, INSERM, EPI 99 30, F-34093 Montpellier, France
关键词
cohorts; incidence study; risk factors; dementia; Alzheimer disease;
D O I
10.1016/S1631-0691(02)01476-2
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Follow-up of cohorts recruited in general population with active screening and diagnosis of incident cases, is the most appropriate epidemiological design for studying incidence and risk factors of Alzheimer disease and other types of dementia. In France, people considered in the PAQUID study, then in the EVA study, have been the first cohorts on dementia. They have prepared the way for the Three-City (3C) study, conducted in Bordeaux, Dijon and Montpellier. About 9500 persons aged 65 years and over have been recruited in these three cities and will be followed-up during four years. The main objective of the 3C study is to investigate the relation between vascular risk and neurodegenerative diseases. The 3C study will provide essential data for defining strategies for dementia prevention. To measure the impact of the strategies on the incidence of dementia and the social burden of this disease will be an important public health objective in the near future.
引用
收藏
页码:665 / 672
页数:8
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