Synthesis and transfection properties of novel non-toxic monocationic lipids. Variation of lipid anchor, spacer and head group structure

被引：33

作者：

Fichert, T ^{[1
]}

Regelin, A ^{[1
]}

Massing, U ^{[1
]}

机构：

[1] Tumor Biol Ctr, Dept Clin Res, D-79106 Freiburg, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(00)00099-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This report describes the synthesis and the transfection properties of novel monocationic non-toxic lipids. We have carried out structural Variations in all three units of the transfection lipid, the lipid anchor, the spacer moiety and the positively charged head group. Our results lead to the conclusion that systematic modification of structural subunits is a promising way to enhance the transfection efficiency. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：787 / 791

页数：5

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