Enzyme Promotes the Hydrogelation from a Hydrophobic Small Molecule

被引：171

作者：

Gao, Jie ^{[2
]}

Wang, Huaimin ^{[2
]}

Wang, Ling ^{[1
]}

Wang, Jingyu ^{[2
]}

Kong, Deling ^{[2
]}

Yang, Zhimou ^{[3
]}

机构：

[1] Nankai Univ, Coll Pharmacol, Tianjin 300071, Peoples R China

[2] Nankai Univ, Minist Educ, Key Lab Bioact Mat, Tianjin 300071, Peoples R China

[3] Nankai Univ, Coll Life Sci, Tianjin Key Lab Prot Sci, Tianjin 300071, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 32期

关键词：

SUPRAMOLECULAR HYDROGEL; IN-VIVO; SELF; NANOFIBERS; NANOSTRUCTURES; ARCHITECTURE; FABRICATION; PEPTIDES; DESIGN; HYBRID;

D O I：

10.1021/ja9042142

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report in this paper that an enzymatic reaction can be used as the sole mechanism for forming supramolecular hydrogels that have good stability in aqueous solutions at room temperature. The gels are two-component hydrogels that are mainly formed by hydrophobic compound 2 and doped with hydrophilic compound 1. They were formed by an enzymatic process that produces hydrophobic 2 in homogeneous modes and assists the formation of three-dimensional networks. We have characterized the morphologies of the gets with scanning electron microscopy and dark-field transmission electron microscopy, collected fluorescence data to monitor the gelation process, and proposed a possible mechanism to explain the formation of the gels.

引用

页码：11286 / +

页数：4

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