Synthesis of the antitumor antibiotic FR-66979: Dmitrienko oxidative expansion of a fully functional core structure

被引：35

作者：

Lim, HJ ^{[1
]}

Sulikowski, GA ^{[1
]}

机构：

[1] TEXAS A&M UNIV,DEPT CHEM,COLLEGE STN,TX 77843

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 30期

关键词：

D O I：

10.1016/0040-4039(96)01109-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A stereocontrolled synthesis of the pentacyclic ring system 18, a projected advanced intermediate in the synthesis of FR-66979 (2), has been achieved, Rey steps in the assembly of 18 include a copper(I) mediated cylization-oxidation of diazoketone 6 to mitosene 16 followed by an oxidative expansion of 16 to 18, The latter transformation proceeds via N-oxidation of diol 17. Copyright (C) 1996 Elsevier Science Ltd

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页码：5243 / 5246

页数：4

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