Predicting full-length transcripts

被引：7

作者：

Brent, MR ^{[1
]}

机构：

[1] Washington Univ, St Louis, MO 63130 USA

来源：

TRENDS IN BIOTECHNOLOGY | 2002年 / 20卷 / 07期

关键词：

D O I：

10.1016/S0167-7799(02)01976-5

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Accurate prediction of the complete structures of protein-coding genes, including 5'-untranslated regions, is crucial for full interpretation of genome sequence, A new report describes the statistical properties of the first exons of genes, and presents a novel statistical method for predicting their boundaries. First exons, which are partially or completely non-coding, have been relatively neglected by gene-finding algorithms. When integrated with other genome annotation tools, this new method will improve the technology of automated genome interpretation.

引用

页码：273 / 275

页数：3

共 20 条

[1] Prediction of complete gene structures in human genomic DNA [J].

Burge, C ;

Karlin, S .

JOURNAL OF MOLECULAR BIOLOGY, 1997, 268 (01) :78-94

[2] Finding the genes in genomic DNA [J].

Burge, CB ;

Karlin, S .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 1998, 8 (03) :346-354

[3] Computational identification of promoters and first exons in the human genome [J].

Davuluri, RV ;

Grosse, I ;

Zhang, MQ .

NATURE GENETICS, 2001, 29 (04) :412-417

[4] RECOGNITION OF PROTEIN CODING REGIONS IN DNA-SEQUENCES [J].

FICKETT, JW .

NUCLEIC ACIDS RESEARCH, 1982, 10 (17) :5303-5318

[5] A computer program for aligning a cDNA sequence with a genomic DNA sequence [J].

Florea, L ;

Hartzell, G ;

Zhang, Z ;

Rubin, GM ;

Miller, W .

GENOME RESEARCH, 1998, 8 (09) :967-974

[6] CPG ISLANDS IN VERTEBRATE GENOMES [J].

GARDINERGARDEN, M ;

FROMMER, M .

JOURNAL OF MOLECULAR BIOLOGY, 1987, 196 (02) :261-282

[7] Gene recognition via spliced sequence alignment [J].

Gelfand, MS ;

Mironov, AA ;

Pevzner, PA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (17) :9061-9066

[8] PREDICTION OF GENE STRUCTURE [J].

GUIGO, R ;

KNUDSEN, S ;

DRAKE, N ;

SMITH, T .

JOURNAL OF MOLECULAR BIOLOGY, 1992, 226 (01) :141-157

[9] Functional annotation of a full-length mouse cDNA collection [J].

Kawai, J ;

Shinagawa, A ;

Shibata, K ;

Yoshino, M ;

Itoh, M ;

Ishii, Y ;

Arakawa, T ;

Hara, A ;

Fukunishi, Y ;

Konno, H ;

Adachi, J ;

Fukuda, S ;

Aizawa, K ;

Izawa, M ;

Nishi, K ;

Kiyosawa, H ;

Kondo, S ;

Yamanaka, I ;

Saito, T ;

Okazaki, Y ;

Gojobori, T ;

Bono, H ;

Kasukawa, T ;

Saito, R ;

Kadota, K ;

Matsuda, H ;

Ashburner, M ;

Batalov, S ;

Casavant, T ;

Fleischmann, W ;

Gaasterland, T ;

Gissi, C ;

King, B ;

Kochiwa, H ;

Kuehl, P ;

Lewis, S ;

Matsuo, Y ;

Nikaido, I ;

Pesole, G ;

Quackenbush, J ;

Schriml, LM ;

Staubli, F ;

Suzuki, R ;

Tomita, M ;

Wagner, L ;

Washio, T ;

Sakai, K ;

Okido, T ;

Furuno, M ;

Aono, H .

NATURE, 2001, 409 (6821) :685-690

[10]

Korf I, 2001, Bioinformatics, V17 Suppl 1, pS140

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