Tissue specificity and the human protein interaction network

被引:247
作者
Bossi, Alice [1 ]
Lehner, Ben [1 ,2 ]
机构
[1] UPF, EMBL CRG Syst Biol Unit, Ctr Genom Regulat, Barcelona 8003, Spain
[2] UPF, ICREA, Ctr Genom Regulat, Barcelona 8003, Spain
基金
欧洲研究理事会;
关键词
human; protein interaction networks; tissue-specific evolution; YEAST; MAP; EXPRESSION; RESOURCE; MOUSE; COMPLEXES; FRAMEWORK; DATABASE; REVEALS;
D O I
10.1038/msb.2009.17
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A protein interaction network describes a set of physical associations that can occur between proteins. However, within any particular cell or tissue only a subset of proteins is expressed and so only a subset of interactions can occur. Integrating interaction and expression data, we analyze here this interplay between protein expression and physical interactions in humans. Proteins only expressed in restricted cell types, like recently evolved proteins, make few physical interactions. Most tissue-specific proteins do, however, bind to universally expressed proteins, and so can function by recruiting or modifying core cellular processes. Conversely, most 'housekeeping' proteins that are expressed in all cells also make highly tissue-specific protein interactions. These results suggest a model for the evolution of tissue-specific biology, and show that most, and possibly all, 'housekeeping' proteins actually have important tissue-specific molecular interactions. Molecular Systems Biology 7 April 2009; doi:10.1038/msb.2009.17
引用
收藏
页数:7
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