Dietary and pharmacological antioxidants in atherosclerosis

被引:88
作者
Stocker, R [1 ]
机构
[1] Heart Res Inst, Biochem Grp, Camperdown, NSW 2050, Australia
关键词
D O I
10.1097/00041433-199912000-00014
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Antioxidants that inhibit LDL oxidation are thought to be potential anti-atherogenic compounds. The results of major human randomized trials with antioxidants have, however, been disappointing, except for probucol, which consistently inhibits restenosis. Similarly, animal intervention studies show that antioxidants do not generally inhibit atherosclerosis, although some compounds provide protection. Direct evidence for the oxidation of LDL causing atherosclerosis is needed. This article summarizes results from antioxidant intervention studies, and highlights some of the key issues that need to be addressed to link biochemical changes in the arterial wall more directly to the oxidation theory of atherosclerosis. Curr Opin Lipidol 10:589-597. (C) 1999 Lippincott Williams & Wilkins.
引用
收藏
页码:589 / 597
页数:9
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