Reanalysis of Tyrannosaurus rex Mass Spectra

被引：54

作者：

Bern, Marshall ^{[1
]}

Phinney, Brett S. ^{[2
]}

Goldberg, David ^{[1
]}

机构：

[1] Palo Alto Res Ctr, Palo Alto, CA 94304 USA

[2] Univ Calif Davis, Genome Ctr, Davis, CA 95616 USA

来源：

JOURNAL OF PROTEOME RESEARCH | 2009年 / 8卷 / 09期

关键词：

dinosaur; fossil; collagen; hemoglobin; contamination; PROTEIN IDENTIFICATION DATA; DATABASE SEARCH; SEQUENCES; MASTODON;

D O I：

10.1021/pr900349r

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Asara et al. reported the detection of collagen peptides in a 68-million-year-old Tyrannosaurus rex bone by shotgun proteomics. This finding has been called into question as a possible statistical artifact. We reanalyze Asara et al.'s tandem mass spectra using a different search engine and different statistical tools. Our reanalysis shows a sample containing common laboratory contaminants, soil bacteria, and bird-like hemoglobin and collagen.

引用

收藏

页码：4328 / 4332

页数：5

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