Lymphatic endothelial regulation, lymphoedema, and lymph node metastadsis

被引：58

作者：

Karkkainen, MJ

Alitalo, K

机构：

[1] Helsinki Univ Hosp, Biomedicum, Haartman Inst, Mol Canc Biol Lab, Helsinki 00014, Finland

[2] Helsinki Univ Hosp, Biomedicum, Haartman Inst, Ludwig Inst Canc Res, Helsinki 00014, Finland

[3] Univ Helsinki, FIN-00014 Helsinki, Finland

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2002年 / 13卷 / 01期

关键词：

lymphangiogenesis; lymphatic vasculature; metastasis; VEGF-C; VEGFR-3;

D O I：

10.1006/scdb.2001.0286

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Vascular endothelial growth factor receptor-3 (VEGFR-3) mediates lymphatic endothelial cell (LEC) growth, migration, and survival by binding VEGF-C and VEGF-D. Recent studies have revealed new regulators of the lymphatic endothelium, such as the transcription factor Prox1, and the cell surface proteins podoplanin and lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1). Furthermore, the isolation of LECs now allows detailed molecular studies of the factors regulating the lymphatic vasculature. These studies are aimed at targeting the lymphatic vasculature in the treatment of various diseases, such as tumour metastasis and lymphoedema.

引用

页码：9 / 18

页数：10

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