Tardive dyskinesia: Possible involvement of free radicals and treatment with vitamin E

被引：86

作者：

Elkashef, AM

Wyatt, RJ

机构：

[1] NIDA, Medicat Dev Div, Bethesda, MD 20892 USA

[2] NIDA, Neuropsychiat Branch, NIH, Bethesda, MD 20892 USA

来源：

SCHIZOPHRENIA BULLETIN | 1999年 / 25卷 / 04期

关键词：

tardive dyskinesia; free radicals; neurodegeneration; vitamin E; antioxidants; neuroleptic;

D O I：

10.1093/oxfordjournals.schbul.a033414

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

A decade ago a hypothesis introduced to explain tardive dyskinesia (TD) implicated free radicals generated secondary to neuroleptic treatment. Since then many preclinical and clinical studies have investigated this possibility. These studies suggest that free radicals are probably involved in the pathogenesis of TD and that vitamin E could be efficacious in its treatment.

引用

页码：731 / 740

页数：10

共 69 条

[61] OXIDATIVE STRESS-INDUCED BY ADMINISTRATION OF THE NEUROLEPTIC DRUG HALOPERIDOL IS ATTENUATED BY HIGHER DOSES OF HALOPERIDOL [J].