Fibrosis of the pancreas:: the initial tissue damage and the resulting pattern

被引：158

作者：

Klöppel, G ^{[1
]}

Detlefsen, S ^{[1
]}

Feyerabend, B ^{[1
]}

机构：

[1] Univ Kiel, Dept Pathol, D-24105 Kiel, Germany

来源：

VIRCHOWS ARCHIV | 2004年 / 445卷 / 01期

关键词：

pancreatic fibrosis; tissue damage; cytokines; pancreatic stellate cells; fibrosis pattern;

D O I：

10.1007/s00428-004-1021-5

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Fibrosis in the pancreas is caused by such processes as necrosis/apoptosis, inflammation or duct obstruction. The initial event that induces fibrogenesis in the pancreas is an injury that may involve the interstitial mesenchymal cells, the duct cells and/or the acinar cells. Damage to any one of these tissue compartments of the pancreas is associated with cytokine-triggered transformation of resident fibroblasts/pancreatic stellate cells into myofibroblasts and the subsequent production and deposition of extracellular matrix. Depending on the site of injury in the pancreas and the involved tissue compartment, predominantly inter(peri)lobular fibrosis (as in alcoholic chronic pancreatitis), periductal fibrosis (as in hereditary pancreatitis), periductal and interlobular fibrosis (as in autoimmune pancreatitis) or diffuse inter- and intralobular fibrosis (as in obstructive chronic pancreatitis) develops.

引用

页码：1 / 8

页数：8

共 41 条

[11] Chronic pancreatitis: Diagnosis, classification, and new genetic developments [J].