Synthesis and evaluation for biological activity of 3-alkyl and 3-halogenoalkyl-quinoxalin-2-ones variously substituted. Part 4

被引：31

作者：

Carta, A

Sanna, P

Loriga, M

Setzu, MG

La Colla, P

Loddo, R

机构：

[1] Univ Sassari, Dipartimento Farm Chim Tossicol, I-07100 Sassari, Italy

[2] Dipartimento Biol Sperimentale, Sez Microbiol, Monserrato, Italy

来源：

FARMACO | 2002年 / 57卷 / 01期

关键词：

2-quinoxalinones; antimicrobial activity; cytotoxic activity;

D O I：

10.1016/S0014-827X(01)01153-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A new series of 3-isopropyl-, 3-trifluoromethyl- and 3-bromomethylquinoxaline-2-ones variously substituted on the benzo-moiety were synthesized and submitted to a preliminary in vitro evaluation for antibacterial, antifungal and anti-HIV activities. Furthermore, all compounds were also tested for cytotoxicity. Results of the screening showed that compound 10 exhibits moderate antimicrobial activity against Staphylococcus aureus (MIC=33 muM), and that 25 and 26 showed interesting cytotoxicity versus mock-infected MT-4 cells. All the other compounds were inactive. (C) 2002 Elsevier Science S.A. All rights reserved.

引用

页码：19 / 25

页数：7

共 11 条

[1] RAPID COLORIMETRIC ASSAY FOR CELL-GROWTH AND SURVIVAL - MODIFICATIONS TO THE TETRAZOLIUM DYE PROCEDURE GIVING IMPROVED SENSITIVITY AND RELIABILITY [J].