Chromosome crosstalk in three dimensions

被引：115

作者：

Gondor, Anita ^{[1
]}

Ohlsson, Rolf ^{[1
]}

机构：

[1] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, SE-17177 Stockholm, Sweden

来源：

NATURE | 2009年 / 461卷 / 7261期

关键词：

CONFORMATION CAPTURE; GENE-EXPRESSION; INTERCHROMOSOMAL ASSOCIATIONS; NUCLEAR ARCHITECTURE; CONTROL REGION; CTCF-BINDING; TRANSCRIPTION; CHROMATIN; ORGANIZATION; RNA;

D O I：

10.1038/nature08453

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The genome forms extensive and dynamic physical interactions with itself in the form of chromosome loops and bridges, thus exploring the three-dimensional space of the nucleus. It is now possible to examine these interactions at the molecular level, and we have gained glimpses of their functional implications. Chromosomal interactions can contribute to the silencing and activation of genes within the three-dimensional context of the nuclear architecture. Technical advances in detecting these interactions contribute to our understanding of the functional organization of the genome, as well as its adaptive plasticity in response to environmental changes during development and disease.

引用

页码：212 / 217

页数：6

共 70 条

[1] Replication in context: dynamic regulation of DNA replication patterns in metazoans [J].

Aladjem, Mirit I. .

NATURE REVIEWS GENETICS, 2007, 8 (08) :588-600

[2] Virus infection induces NF-κB-dependent interchromosomal associations mediating monoallelic IFN-β gene expression [J].

Apostolou, Effie ;

Thanos, Dimitris .

CELL, 2008, 134 (01) :85-96

[3] Specialized transcription factories [J].

Bartlett, O ;

Blagojevic, J ;

Carter, D ;

Eskiw, C ;

Fromaget, M ;

Job, C ;

Shamsher, M ;

Trindade, IF ;

Xu, M ;

Cook, PR .

TRANSCRIPTION, 2006, 73 :67-75

[4] Intermingling of chromosome territories in interphase suggests role in translocations and transcription-dependent associations [J].

Branco, Miguel R. ;

Pombo, Ana .

PLOS BIOLOGY, 2006, 4 (05) :780-788

[5] Association between active genes occurs at nuclear speckles and is modulated by chromatin environment [J].

Brown, Jill M. ;

Green, Joanne ;

das Neves, Ricardo Pires ;

Wallace, Helen A. C. ;

Smith, Andrew J. H. ;

Hughes, Jim ;

Gray, Nicki ;

Taylor, Steve ;

Wood, William G. ;

Higgs, Douglas R. ;

Iborra, Francisco J. ;

Buckle, Veronica J. .

JOURNAL OF CELL BIOLOGY, 2008, 182 (06) :1083-1097

[6] Chromatin Insulators: Regulatory Mechanisms and Epigenetic Inheritance [J].

Bushey, Ashley M. ;

Dorman, Elizabeth R. ;

Corces, Victor G. .

MOLECULAR CELL, 2008, 32 (01) :1-9

[7] SATB1 packages densely looped, transcriptionally active chromatin for coordinated expression of cytokine genes [J].

Cai, Shutao ;

Lee, Charles C. ;

Kohwi-Shigematsu, Terumi .

NATURE GENETICS, 2006, 38 (11) :1278-1288

[8] Replication and transcription: Shaping the landscape of the genome [J].

Chakalova, L ;

Debrand, E ;

Mitchell, JA ;

Osborne, CS ;

Fraser, P .

NATURE REVIEWS GENETICS, 2005, 6 (09) :669-677

[9] A novel role for Xist RNA in the formation of a repressive nuclear compartment into which genes are recruited when silenced [J].

Chaumeil, Julie ;

Le Baccon, Patricia ;

Wutz, Anton ;

Heard, Edith .

GENES & DEVELOPMENT, 2006, 20 (16) :2223-2237

[10] Molecular biology - The organization of replication and transcription [J].

Cook, PR .

SCIENCE, 1999, 284 (5421) :1790-1795

← 1 2 3 4 5 6 7 →