Integrated wireless neural interface based on the Utah electrode array

被引:118
作者
Kim, S. [1 ]
Bhandari, R. [1 ]
Klein, M. [2 ]
Negi, S. [1 ]
Rieth, L. [1 ]
Tathireddy, P. [1 ]
Toepper, M. [2 ]
Oppermann, H. [2 ]
Solzbacher, F. [1 ]
机构
[1] Univ Utah, Dept Elect & Comp Engn, Salt Lake City, UT 84112 USA
[2] Fraunhofer Inst Reliabil & Microintegrat IZM, D-13355 Berlin, Germany
关键词
Utah electrode array (UEA); Neural interface; Neural microelectrode; Under bump metallization (UBM); Flip chip bonding; Hybrid integration; 3-DIMENSIONAL MICROELECTRODE ARRAY; TELEMETRY; MICROSYSTEMS; DEVICES; SYSTEM;
D O I
10.1007/s10544-008-9251-y
中图分类号
R318 [生物医学工程];
学科分类号
100103 [病原生物学];
摘要
This report presents results from research towards a fully integrated, wireless neural interface consisting of a 100-channel microelectrode array, a custom-designed signal processing and telemetry IC, an inductive power receiving coil, and SMD capacitors. An integration concept for such a device was developed, and the materials and methods used to implement this concept were investigated. We developed a multi-level hybrid assembly process that used the Utah Electrode Array (UEA) as a circuit board. The signal processing IC was flip-chip bonded to the UEA using Au/Sn reflow soldering, and included amplifiers for up to 100 channels, signal processing units, an RF transmitter, and a power receiving and clock recovery module. An under bump metallization (UBM) using potentially biocompatible materials was developed and optimized, which consisted of a sputter deposited Ti/Pt/Au thin film stack with layer thicknesses of 50/150/150 nm, respectively. After flip-chip bonding, an underfiller was applied between the IC and the UEA to improve mechanical stability and prevent fluid ingress in in vivo conditions. A planar power receiving coil fabricated by patterning electroplated gold films on polyimide substrates was connected to the IC by using a custom metallized ceramic spacer and SnCu reflow soldering. The SnCu soldering was also used to assemble SMD capacitors on the UEA. The mechanical properties and stability of the optimized interconnections between the UEA and the IC and SMD components were measured. Measurements included the tape tests to evaluate UBM adhesion, shear testing between the Au/Sn solder bumps and the substrate, and accelerated lifetime testing of the long-term stability for the underfiller material coated with a a-SiCx:H by PECVD, which was intended as a device encapsulation layer. The materials and processes used to generate the integrated neural interface device were found to yield a robust and reliable integrated package.
引用
收藏
页码:453 / 466
页数:14
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