Electroporation for the Delivery of DNA-based Vaccines and Immunotherapeutics: Current Clinical Developments

被引：157

作者：

Bodles-Brakhop, Angela M. ^{[1
]}

Heller, Richard ^{[2
]}

Draghia-Akli, Ruxandra ^{[1
]}

机构：

[1] VGX Pharmaceut Inc, Res, The Woodlands, TX 77381 USA

[2] Old Dominion Univ, Frank Reidy Res Ctr Bioelect, Norfolk, VA USA

来源：

MOLECULAR THERAPY | 2009年 / 17卷 / 04期

关键词：

IN-VIVO ELECTROPORATION; REFRACTORY PROSTATE-CANCER; MOUSE MELANOMA MODEL; T-CELL RESPONSES; HUMAN-PAPILLOMAVIRUS; GENE-TRANSFER; IMMUNE-RESPONSES; RHESUS MACAQUES; PLASMID ELECTROPORATION; DENDRITIC CELLS;

D O I：

10.1038/mt.2009.5

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Electroporation (EP) has been used in basic research for the past 25 years to aid in the transfer of DNA into cells in vitro. EP in vivo enhances transfer of DNA vaccines and therapeutic plasmids to the skin, muscle, tumors, and other tissues resulting in high levels of expression, often with serological and clinical benefits. the recent interest in nonviral gene transfer as treatment options for a vast array of conditions has resulted in the refinement and optimization of EP technology. current research has revealed that EP can be successfully used in many species, including humans. clinical trials are currently under way. Herein, the transition of EP from basic science to clinical trials will be discussed.

引用

页码：585 / 592

页数：8

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