Candida albicans-derived β-1,2-linked mannooligosaccharides induce desensitization of macrophages

被引：28

作者：

Jouault, T ^{[1
]}

Fradin, C ^{[1
]}

Trinel, PA ^{[1
]}

Poulain, D ^{[1
]}

机构：

[1] Univ Lille 2, INSERM E9915, Lab Mycol Fondamentale & Appl, Fac Med, F-59037 Lille, France

来源：

INFECTION AND IMMUNITY | 2000年 / 68卷 / 02期

关键词：

D O I：

10.1128/IAI.68.2.965-968.2000

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Candida albicans beta-1,2-oligomannosides stimulate macrophage tumor necrosis factor alpha (TNF-alpha) but not NO release. This stimulation desensitized macrophages by altering beta-1,2-oligomannoside-dependent TNF-alpha production and lipopolysaccharide-dependent TNF-alpha and NO secretion. Desensitization was not related to tyrosine phosphorylation signal transduction but was transferred by culture supernatants in which arachidonic acid derivatives were evidenced.

引用

页码：965 / 968

页数：4

共 31 条

[1]

ALLEVA DG, 1994, J IMMUNOL, V153, P1674

[2] PROLIFERATION OF HUMAN PERIPHERAL-BLOOD MONONUCLEAR-CELLS INDUCED BY CANDIDA-ALBICANS AND ITS CELL-WALL FRACTIONS [J].

AUSIELLO, CM ;

SPAGNOLI, GC ;

BOCCANERA, M ;

CASALINUOVO, I ;

MALAVASI, F ;

CASCIANI, CU ;

CASSONE, A .

JOURNAL OF MEDICAL MICROBIOLOGY, 1986, 22 (03) :195-202

[3] RATS CLEARING A VAGINAL INFECTION BY CANDIDA-ALBICANS ACQUIRE SPECIFIC, ANTIBODY-MEDIATED RESISTANCE TO VAGINAL REINFECTION [J].

CASSONE, A ;

BOCCANERA, M ;

ADRIANI, D ;

SANTONI, G ;

DEBERNARDIS, F .

INFECTION AND IMMUNITY, 1995, 63 (07) :2619-2624

[4] CANDIDA-ALBICANS STIMULATES ARACHIDONIC-ACID LIBERATION FROM ALVEOLAR MACROPHAGES THROUGH ALPHA-MANNAN AND BETA-GLUCAN CELL-WALL COMPONENTS [J].

CASTRO, M ;

RALSTON, NVC ;

MORGENTHALER, TI ;

ROHRBACH, MS ;

LIMPER, AH .

INFECTION AND IMMUNITY, 1994, 62 (08) :3138-3145

[5]

Chinen T, 1999, CLIN EXP IMMUNOL, V115, P491

[6] ENDOTOXIN TOLERANCE IS ASSOCIATED WITH ALTERED GTP-BINDING PROTEIN FUNCTION [J].

COFFEE, KA ;

HALUSHKA, PV ;

ASHTON, SH ;

TEMPEL, GE ;

WISE, WC ;

COOK, JA .

JOURNAL OF APPLIED PHYSIOLOGY, 1992, 73 (03) :1008-1013

[7] RAPID KILLING OF MONOCYTES INVITRO BY CANDIDA-ALBICANS YEAST-CELLS [J].

DANLEY, DL ;

POLAKOFF, J .

INFECTION AND IMMUNITY, 1986, 51 (01) :307-313

[8] CANDIDA-SPECIFIC TH1-TYPE RESPONSIVENESS IN MICE WITH EXPERIMENTAL VAGINAL CANDIDIASIS [J].

FIDEL, PL ;

LYNCH, ME ;

SOBEL, JD .

INFECTION AND IMMUNITY, 1993, 61 (10) :4202-4207

[9] SECRETION OF TNF-ALPHA BY ALVEOLAR MACROPHAGES IN RESPONSE TO CANDIDA-ALBICANS MANNAN [J].

GARNER, RE ;

RUBANOWICE, K ;

SAWYER, RT ;

HUDSON, JA .

JOURNAL OF LEUKOCYTE BIOLOGY, 1994, 55 (02) :161-168

[10] Biochemical characterization of Candida albicans epitopes that can elicit protective and nonprotective antibodies [J].

Han, Y ;

Kanbe, T ;

Cherniak, R ;

Cutler, JE .

INFECTION AND IMMUNITY, 1997, 65 (10) :4100-4107

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