Candida albicans-derived β-1,2-linked mannooligosaccharides induce desensitization of macrophages

被引：28

作者：

Jouault, T ^{[1
]}

Fradin, C ^{[1
]}

Trinel, PA ^{[1
]}

Poulain, D ^{[1
]}

机构：

[1] Univ Lille 2, INSERM E9915, Lab Mycol Fondamentale & Appl, Fac Med, F-59037 Lille, France

来源：

INFECTION AND IMMUNITY | 2000年 / 68卷 / 02期

关键词：

D O I：

10.1128/IAI.68.2.965-968.2000

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Candida albicans beta-1,2-oligomannosides stimulate macrophage tumor necrosis factor alpha (TNF-alpha) but not NO release. This stimulation desensitized macrophages by altering beta-1,2-oligomannoside-dependent TNF-alpha production and lipopolysaccharide-dependent TNF-alpha and NO secretion. Desensitization was not related to tyrosine phosphorylation signal transduction but was transferred by culture supernatants in which arachidonic acid derivatives were evidenced.

引用

页码：965 / 968

页数：4

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