Alkaloid 223A: The first trisubstituted indolizidine from dendrobatid frogs

被引：32

作者：

Garraffo, HM ^{[1
]}

Jain, P ^{[1
]}

Spande, TF ^{[1
]}

Daly, JW ^{[1
]}

机构：

[1] NIDDKD,LAB BIOORGAN CHEM,NIH,BETHESDA,MD 20892

来源：

JOURNAL OF NATURAL PRODUCTS | 1997年 / 60卷 / 01期

关键词：

D O I：

10.1021/np960522l

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The structure of alkaloid 223A (1), the first member of a new class of amphibian alkaloids, purified by HPLC from a skin extract of a Panamanian population of the frog Dendrobates pumilio Schmidt (Dendrobatidae), has been established as (5R,6S,8R,9S)- or (5S,6R,8S,9R)-6,8-diethyl-5-propylindolizidine, based on GC-MS, GC-FTIR, and H-1-NMR spectral studies. Three higher homologs of 223A, namely alkaloids 237L (2), 251M (3), and 267J (4), have been detected in other extracts, and tentative structures are proposed.

引用

页码：2 / 5

页数：4

共 14 条

[11] INVESTIGATION OF NITROGEN-CONTAINING COMPOUNDS OF CASTOREUM [J].