Circular RNAs open a new chapter in cardiovascular biology

被引：429

作者：

Aufiero, Simona ^{[1
,2
]}

Reckman, Yolan J. ^{[1
]}

Pinto, Yigal M. ^{[1
]}

Creemers, Esther E. ^{[1
]}

机构：

[1] Univ Amsterdam, Amsterdam UMC, Dept Expt Cardiol, Amsterdam, Netherlands

[2] Univ Amsterdam, Amsterdam UMC, Dept Clin Epidemiol Biostat & Bioinformat, Amsterdam, Netherlands

来源：

NATURE REVIEWS CARDIOLOGY | 2019年 / 16卷 / 08期

关键词：

MESSENGER-RNA; CELLS PROLIFERATION; ENDOTHELIAL-CELLS; EXPRESSION; GENE; IDENTIFICATION; TRANSLATION; REVEALS; BIOGENESIS; ABUNDANT;

D O I：

10.1038/s41569-019-0185-2

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Circular RNAs (circRNAs) are emerging as a new class of non-coding RNA molecules. This unusual class of RNA species is generated by a back-splicing event of one or two exons, resulting in a covalently closed circRNA molecule. Owing to their circular form, circRNAs are protected from degradation by exonucleases and have greater stability than linear RNA. Advances in computational analysis of RNA sequencing have revealed that thousands of different circRNAs are expressed in a wide range of mammalian tissues, including the cardiovascular system. Moreover, numerous circRNAs are expressed in a disease-specific manner. A great deal of progress has been made in understanding the biogenesis and function of these circRNAs. In this Review, we discuss the current understanding of circRNA biogenesis and function, with a particular emphasis on the cardiovascular system.

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收藏

页码：503 / 514

页数：12

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