Aldol reaction under solvent-free conditions: Highly stereoselective synthesis of 1,3-amino alcohols

被引：58

作者：

Loh, TP ^{[1
]}

Huang, JM ^{[1
]}

Goh, SH ^{[1
]}

Vittal, JJ ^{[1
]}

机构：

[1] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 09期

关键词：

D O I：

10.1021/ol000042s

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A method for the highly stereoselective synthesis of 1,3-amino alcohols based on the indium trichloride-catalyzed Mukaiyama aldol reaction of keto ester (R,S)-1 under solvent-free conditions has been developed, The high selectivity observed can be explained on the basis of the shielding of one face by a remote substituent.

引用

页码：1291 / 1294

页数：4

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