Synthesis and spectroscopic characterization of β-di-, β-tri-, and β-hexapeptides built with (S)-2-methylene-3-aminoalkanoic acids derived from alanine, valine, and leucine

被引：9

作者：

Bierbaum, DJ ^{[1
]}

Seebach, D ^{[1
]}

机构：

[1] ETH Honggerberg, Organ Chem Lab, HCI, CH-8093 Zurich, Switzerland

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 2004年 / 57卷 / 09期

关键词：

D O I：

10.1071/CH04052

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Methylthiomethylation and subsequent sulfoxidation and pyrolysis of the N-Boc-protected beta(3)-amino acid methyl esters derived from Ala, Val, and Leu provided the alpha-methylene esters; these were then used to synthesize the beta-peptides specified in the title (step-by-step and fragment coupling in solution). The novel beta-peptides were fully characterized, but neither solid-state nor solution structures were found.

引用

页码：859 / 863

页数：5

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