Selective hydrogenation of benzophenones to benzhydrols. Asymmetric synthesis of unsymmetrical diarylmethanols

被引：188

作者：

Ohkuma, T

Koizumi, M

Ikehira, H

Yokozawa, T

Noyori, R ^{[1
]}

机构：

[1] Nagoya Univ, Dept Chem, Chikusa Ku, Nagoya, Aichi 4648602, Japan

[2] Nagoya Univ, Res Ctr Mat Sci, Chikusa Ku, Nagoya, Aichi 4648602, Japan

[3] Japan Sci & Technol Corp, ERATO, Mol Catalysis Project, Toyota 4700392, Japan

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 05期

关键词：

D O I：

10.1021/ol9904139

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] trans-RuCl2[P(C6H4-4-CH3)(3)](2)(NH2CH2CH2NH2) acts as a highly effective precatalyst for the hydrogenation of a variety of benzophenone derivatives to benzhydrols that proceeds smoothly at 8 atm and 23-35 degrees C in 2-propanol containing t-C4H9OK with a substrate/catalyst ratio of 2000-20000. Use of a BINAP/chiral diamine Ru complex effects asymmetric hydrogenation of various ortho-substituted benzophenones and benzoylferrocene to chiral diarylmethanols with consistently high ee.

引用

页码：659 / 662

页数：4

共 53 条

[51] TI-TADDOLATE-CATALYZED, HIGHLY ENANTIOSELECTIVE ADDITION OF ALKYL-TITANIUM AND ARYL-TITANIUM DERIVATIVES TO ALDEHYDES [J].