Human fasting plasma concentrations of vitamin E and carotenoids, and their association with genetic variants in apo C-III, cholesteryl ester transfer protein, hepatic lipase, intestinal fatty acid binding protein and microsomal triacylglycerol transfer protein

被引:52
作者
Borel, Patrick [1 ,2 ,3 ]
Moussa, Myriam [1 ,2 ,3 ]
Reboul, Emmanuelle [1 ,2 ,3 ]
Lyan, Bernard [4 ]
Defoort, Catherine [1 ,2 ,3 ]
Vincent-Baudry, Stephanie [1 ,2 ,3 ]
Maillot, Matthieu [1 ,2 ,3 ]
Gastaldi, Marguerite [1 ,2 ,3 ]
Darmon, Michel [1 ,2 ,3 ]
Portugal, Henri [1 ,2 ,3 ]
Lairon, Denis [1 ,2 ,3 ]
Planells, Richard [1 ,2 ,3 ]
机构
[1] INRA, UMR Nutriments Lipid & Prevent Malad Metab 1260, F-13385 Marseille, France
[2] INSERM, U476, F-13385 Marseille, France
[3] Univ Aix Marseille 2, Univ Aix Marseille 1, Fac Med, IPHM IFR 125, F-13385 Marseille, France
[4] INRA, UMR Nutr Humaine 1019, F-63122 St Genes Champanelle, France
关键词
Carotene; Intestinal fatty acid binding protein; Lycopene; Single nucleotide polymorphisms; Tocopherols; HIGH-DENSITY-LIPOPROTEIN; I SR-BI; ALPHA-TOCOPHEROL; MEDI-RIVAGE; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; PROMOTER ACTIVITY; E TRANSPORT; POLYMORPHISM; ATHEROSCLEROSIS;
D O I
10.1017/S0007114508030754
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Plasma concentrations of vitamin E and carotenoids are governed by several factors, including genetic factors. Single nucleotide polymorphisms (SNP) in some genes involved in lipid metabolism have recently been associated with fasting plasma concentrations of these fat-soluble micronutrients. To further investigate the role of genetic factors that modulate the plasma concentrations of these micronutrients, we assessed whether SNP in five candidate genes (apo C-III, CETP, hepatic lipase, I-FABP and MTP) were associated with the plasma concentrations of these micronutrients. Fasting plasma vitamin E and carotenoid concentrations were measured in 129 French Caucasian subjects (forty-eight males and eighty-one females). Candidate SNP were genotyped by PCR amplification followed by restriction fragment length polymorphisms. Plasma gamma-tocopherol, alpha-carotene and beta-carotene concentrations were significantly different (P<0.05) in subjects who carried different SNP variants in hepatic lipase. Plasma alpha-tocopherol concentrations were significantly different in subjects who had different SNP variants in apo C-III and cholesteryl ester transfer protein (CETP). Plasma lycopene concentrations were significantly different (P<0.05) in women who had different SNP variants in intestinal fatty acid binding protein (I-FABP). Finally, there was no effect of SNP variants in microsomal TAG transfer protein upon the plasma concentrations of these micronutrients. Most of the observed differences remained significant after the plasma micronutrients were adjusted for plasma TAG and cholesterol. These results suggest that apo C-III, CETP and hepatic lipase play a role in determining the plasma concentrations of tocopherols while hepatic lipase and I-FABP may modulate plasma concentrations of carotenoids.
引用
收藏
页码:680 / 687
页数:8
相关论文
共 53 条
[1]   Mechanisms involved in vitamin E transport by primary enterocytes and in vivo absorption [J].
Anwar, Kamran ;
Iqbal, Jahangir ;
Hussain, M. Mahmood .
JOURNAL OF LIPID RESEARCH, 2007, 48 (09) :2028-2038
[2]   AN AMINO-ACID SUBSTITUTION IN THE HUMAN INTESTINAL FATTY-ACID-BINDING PROTEIN IS ASSOCIATED WITH INCREASED FATTY-ACID-BINDING, INCREASED FAT OXIDATION, AND INSULIN-RESISTANCE [J].
BAIER, LJ ;
SACCHETTINI, JC ;
KNOWLER, WC ;
EADS, J ;
PAOLISSO, G ;
TATARANNI, PA ;
MOCHIZUKI, H ;
BENNETT, PH ;
BOGARDUS, C ;
PROCHAZKA, M .
JOURNAL OF CLINICAL INVESTIGATION, 1995, 95 (03) :1281-1287
[3]   CETP and atherosclerosis [J].
Barter, P .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2000, 20 (09) :2029-2031
[4]   TRANSPORT OF ALPHA-TOCOPHEROL AND GAMMA-TOCOPHEROL IN HUMAN-PLASMA LIPOPROTEINS [J].
BEHRENS, WA ;
MADERE, R .
NUTRITION RESEARCH, 1985, 5 (02) :167-174
[5]   New insights into the fatty acid-binding protein (FABP) family in the small intestine [J].
Besnard, P ;
Niot, I ;
Poirier, H ;
Clément, L ;
Bernard, A .
MOLECULAR AND CELLULAR BIOCHEMISTRY, 2002, 239 (1-2) :139-147
[6]  
BONE RA, 1993, INVEST OPHTH VIS SCI, V34, P2033
[7]   Factors affecting intestinal absorption of highly lipophilic food microconstituents (fat-soluble vitamins, carotenoids and phytosterols) [J].
Borel, P .
CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2003, 41 (08) :979-994
[8]   Human plasma levels of vitamin E and Carotenoids are associated with genetic polymorphisms in genes involved in lipid metabolism [J].
Borel, Patrick ;
Moussa, Myriam ;
Reboul, Emmanuelle ;
Lyan, Bernard ;
Defoort, Catherine ;
Vincent-Baudry, Stephanie ;
Maillot, Matthieu ;
Gastaldi, Marguerite ;
Darmon, Michel ;
Portugal, Henri ;
Planells, Richard ;
Lairon, Denis .
JOURNAL OF NUTRITION, 2007, 137 (12) :2653-2659
[9]   Hepatic lipase promoter activity is reduced by the C-480T and G-216A substitutions present in the common LIPC gene variant, and is increased by Upstream Stimulatory Factor [J].
Botma, GJ ;
Verhoeven, AJM ;
Jansen, H .
ATHEROSCLEROSIS, 2001, 154 (03) :625-632
[10]  
CLEVIDENCE BA, 1993, METHOD ENZYMOL, V214, P33