The role of calcium in the regulation of apoptosis

被引：386

作者：

McConkey, DJ ^{[1
]}

Orrenius, S ^{[1
]}

机构：

[1] KAROLINSKA INST, INST ENVIRONM MED, DIV TOXICOL, S-10401 STOCKHOLM, SWEDEN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1997年 / 239卷 / 02期

关键词：

D O I：

10.1006/bbrc.1997.7409

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Apoptosis (programmed cell death) has gained widespread attention due to its roles in a variety of physiological and pathological processes, yet precisely how apoptosis is regulated by external and internal cues remains unclear. Work from our laboratories and others has implicated alterations in intracellular Ca2+ in apoptosis, and more recent work has defined particular biochemical processes that are targeted by Ca2+ in apoptotic cells. This review will summarize the role of Ca2+ in apoptosis within the context of what is known about the core components of the effector machinery for apoptosis. (C) 1997 Academic Press.

引用

页码：357 / 366

页数：10

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