The role of calcium in the regulation of apoptosis

被引：386

作者：

McConkey, DJ ^{[1
]}

Orrenius, S ^{[1
]}

机构：

[1] KAROLINSKA INST, INST ENVIRONM MED, DIV TOXICOL, S-10401 STOCKHOLM, SWEDEN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1997年 / 239卷 / 02期

关键词：

D O I：

10.1006/bbrc.1997.7409

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Apoptosis (programmed cell death) has gained widespread attention due to its roles in a variety of physiological and pathological processes, yet precisely how apoptosis is regulated by external and internal cues remains unclear. Work from our laboratories and others has implicated alterations in intracellular Ca2+ in apoptosis, and more recent work has defined particular biochemical processes that are targeted by Ca2+ in apoptotic cells. This review will summarize the role of Ca2+ in apoptosis within the context of what is known about the core components of the effector machinery for apoptosis. (C) 1997 Academic Press.

引用

页码：357 / 366

页数：10

共 106 条

[61] X-ray and NMR structure of human Bcl-x(L), an inhibitor of programmed cell death [J].

Muchmore, SW ;

Sattler, M ;

Liang, H ;

Meadows, RP ;

Harlan, JE ;

Yoon, HS ;

Nettesheim, D ;

Chang, BS ;

Thompson, CB ;

Wong, SL ;

Ng, SC ;

Fesik, SW .

NATURE, 1996, 381 (6580) :335-341

[62] FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex [J].

Muzio, M ;

Chinnaiyan, AM ;

Kischkel, FC ;

ORourke, K ;

Shevchenko, A ;

Ni, J ;

Scaffidi, C ;

Bretz, JD ;

Zhang, M ;

Gentz, R ;

Mann, M ;

Krammer, PH ;

Peter, ME ;

Dixit, VM .

CELL, 1996, 85 (06) :817-827

[63] THE FAS DEATH FACTOR [J].

NAGATA, S ;

GOLSTEIN, P .

SCIENCE, 1995, 267 (5203) :1449-1456

[64] INVIVO CALCIUM ELEVATIONS IN THYMOCYTES WITH T-CELL RECEPTORS THAT ARE SPECIFIC FOR SELF LIGANDS [J].

NAKAYAMA, T ;

UEDA, Y ;

YAMADA, H ;

SHORES, EW ;

SINGER, A ;

JUNE, CH .

SCIENCE, 1992, 257 (5066) :96-99

[65] Non-erythroid alpha-spectrin breakdown by calpain and interleukin 1 beta-converting-enzyme-like protease(s) in apoptotic cells: Contributory roles of both protease families in neuronal apoptosis [J].

Nath, R ;

Raser, KJ ;

Stafford, D ;

Hajimohammadreza, I ;

Posner, A ;

Allen, H ;

Talanian, RV ;

Yuen, PW ;

Gilbertsen, RB ;

Wang, KKW .

BIOCHEMICAL JOURNAL, 1996, 319 :683-690

[66]

NEAMATI N, 1995, J IMMUNOL, V154, P3788

[67] PROPERTIES OF SOME NUCLEAR NUCLEASES OF RAT THYMOCYTES AND THEIR CHANGES IN RADIATION-INDUCED APOPTOSIS [J].

NIKONOVA, LV ;

BELETSKY, IP ;

UMANSKY, SR .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1993, 215 (03) :893-901

[68] APOPTOTIC DEATH IN EPITHELIAL-CELLS - CLEAVAGE OF DNA TO 300 AND OR 50 KB FRAGMENTS PRIOR TO OR IN THE ABSENCE OF INTERNUCLEOSOMAL FRAGMENTATION [J].

OBERHAMMER, F ;

WILSON, JW ;

DIVE, C ;

MORRIS, ID ;

HICKMAN, JA ;

WAKELING, AE ;

WALKER, PR ;

SIKORSKA, M .

EMBO JOURNAL, 1993, 12 (09) :3679-3684

[69] ROLE OF CA-2+ IN TOXIC CELL KILLING [J].

ORRENIUS, S ;

MCCONKEY, DJ ;

BELLOMO, G ;

NICOTERA, P .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1989, 10 (07) :281-285

[70] CHARACTERIZATION OF THE ENDOGENOUS DEOXYRIBONUCLEASE INVOLVED IN NUCLEAR-DNA DEGRADATION DURING APOPTOSIS (PROGRAMMED CELL-DEATH) [J].

PEITSCH, MC ;

POLZAR, B ;

STEPHAN, H ;

CROMPTON, T ;

MACDONALD, HR ;

MANNHERZ, HG ;

TSCHOPP, J .

EMBO JOURNAL, 1993, 12 (01) :371-377

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