Update on mechanism and catalytic regulation in the NO synthases

被引:401
作者
Stuehr, DJ [1 ]
Santolini, J [1 ]
Wang, ZQ [1 ]
Wei, CC [1 ]
Adak, S [1 ]
机构
[1] Cleveland Clin Fdn, Lerner Res Inst, Dept Immunol, Cleveland, OH 44195 USA
关键词
D O I
10.1074/jbc.R400017200
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:36167 / 36170
页数:4
相关论文
共 48 条
[1]   Regulation of inducible nitric oxide synthase by self-generated NO [J].
Abu-Soud, HM ;
Ichimori, K ;
Nakazawa, H ;
Stuehr, DJ .
BIOCHEMISTRY, 2001, 40 (23) :6876-6881
[2]   Electron transfer, oxygen binding, and nitric oxide feedback inhibition in endothelial nitric-oxide synthase [J].
Abu-Soud, HM ;
Ichimori, K ;
Presta, A ;
Stuehr, DJ .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (23) :17349-17357
[3]   NEURONAL NITRIC-OXIDE SYNTHASE SELF-INACTIVATES BY FORMING A FERROUS-NITROSYL COMPLEX DURING AEROBIC CATALYSIS [J].
ABUSOUD, HM ;
WANG, JL ;
ROUSSEAU, DL ;
FUKUTO, JM ;
IGNARRO, LJ ;
STUEHR, DJ .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (39) :22997-23006
[4]   Arginine conversion to nitroxide by tetrahydrobiopterin-free neuronal nitric-oxide synthase - Implications for mechanism [J].
Adak, S ;
Wang, Q ;
Stuehr, DJ .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (43) :33554-33561
[5]   Molecular basis for hyperactivity in tryptophan 409 mutants of neuronal NO synthase [J].
Adak, S ;
Wang, Q ;
Stuehr, DJ .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (23) :17434-17439
[6]   Chimeras of nitric-oxide synthase types I and III establish fundamental correlates between heme reduction, heme-NO complex formation, and catalytic activity [J].
Adak, S ;
Aulak, KS ;
Stuehr, DJ .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (26) :23246-23252
[7]   Neuronal nitric-oxide synthase mutant (Ser-1412 → Asp) demonstrates surprising connections between heme reduction, NO complex formation, and catalysis [J].
Adak, S ;
Santolini, J ;
Tikunova, S ;
Wang, Q ;
Johnson, JD ;
Stuehr, DJ .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (02) :1244-1252
[8]   Reduced oxy intermediate observed in D251N cytochrome P450(cam) [J].
Benson, DE ;
Suslick, KS ;
Sligar, SG .
BIOCHEMISTRY, 1997, 36 (17) :5104-5107
[9]   Crystal structure of SANOS, a bacterial nitric oxide synthase oxygenase protein from Staphylococcus aureus [J].
Bird, LE ;
Ren, JS ;
Zhang, JC ;
Foxwell, N ;
Hawkins, AR ;
Charles, IG ;
Stammers, DK .
STRUCTURE, 2002, 10 (12) :1687-1696
[10]   Nitric oxide and iron proteins [J].
Cooper, CE .
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 1999, 1411 (2-3) :290-309